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Documentos Principais

O0266

Sigma-Aldrich

Obestatin mouse, rat

synthetic

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About This Item

Fórmula empírica (Notação de Hill):
C114H174N34O31
Número CAS:
Peso molecular:
2516.81
Número MDL:
Código UNSPSC:
51111800
ID de substância PubChem:
NACRES:
NA.32
fonte biológica:
synthetic
Formulário:
lyophilized powder
Ensaio:
≥97% (HPLC)

fonte biológica

synthetic

Ensaio

≥97% (HPLC)

Formulário

lyophilized powder

cor

white

solubilidade

deionized water: 0.5-1 mg/mL

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc3ccccc3)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc4ccc(O)cc4)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(N)=O

InChI

1S/C114H174N34O31/c1-12-60(8)93(146-90(157)54-128-111(177)92(59(6)7)147-109(175)81(50-91(158)159)143-108(174)78(46-65-25-17-14-18-26-65)144-110(176)83-29-22-42-148(83)113(179)63(11)132-105(171)80(49-87(120)154)139-97(163)69(116)45-64-23-15-13-16-24-64)112(178)137-71(27-19-20-40-115)101(167)140-76(44-58(4)5)106(172)145-82(55-149)99(165)127-52-88(155)130-61(9)95(161)134-72(34-37-84(117)151)103(169)141-77(47-66-30-32-68(150)33-31-66)107(173)136-73(35-38-85(118)152)102(168)135-74(36-39-86(119)153)104(170)142-79(48-67-51-124-56-129-67)98(164)126-53-89(156)133-70(28-21-41-125-114(122)123)100(166)131-62(10)96(162)138-75(94(121)160)43-57(2)3/h13-18,23-26,30-33,51,56-63,69-83,92-93,149-150H,12,19-22,27-29,34-50,52-55,115-116H2,1-11H3,(H2,117,151)(H2,118,152)(H2,119,153)(H2,120,154)(H2,121,160)(H,124,129)(H,126,164)(H,127,165)(H,128,177)(H,130,155)(H,131,166)(H,132,171)(H,133,156)(H,134,161)(H,135,168)(H,136,173)(H,137,178)(H,138,162)(H,139,163)(H,140,167)(H,141,169)(H,142,170)(H,143,174)(H,144,176)(H,145,172)(H,146,157)(H,147,175)(H,158,159)(H4,122,123,125)/t60-,61-,62-,63-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,92-,93-/m0/s1

chave InChI

OJSXICLEROKMBP-FFUDWAICSA-N

Informações sobre genes

mouse ... Ghrl(58991)
rat ... Ghrl(59301)

Amino Acid Sequence

Phe-Asn-Ala-Pro-Phe-Asp-Val-Gly-Ile-Lys-Leu-Ser-Gly-Ala-Gln-Tyr-Gln-Gln-His-Gly-Arg-Ala-Leu-NH2

Descrição geral

Obestatin is a 23 amino acid bioactive peptide encoded by the ghrelin gene.

Aplicação

Obestatin has been used to study its effect on serum glucose and enzymatic parameters in rats and used to investigate its effect on plasma acyl-ghrelin and body weight in wistar rat.

Ações bioquímicas/fisiológicas

Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).
Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

forma física

Lyophilized from 0.1% aqueous trifluoroacetate (TFA).

Outras notas

Lyophilized from 0.1% TFA in H2O

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Visite a Biblioteca de Documentos

Eman F Khaleel et al.
Archives of physiology and biochemistry, 125(1), 64-78 (2018-02-13)
This study investigated the ameliorative and protective effects of long-term obestatin administration (80 nmol/kg/ intraperitoneal injection (i.p.)) on the pathogenesis of high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) in rats. Rats (n = 8/group) were divided as control, NAFLD, NAFLD + Simvastatin, NAFLD + obestatin
Obestatin does not activate orphan G protein-coupled receptor GPR39.
Lauwers E
Biochemical and Biophysical Research Communications, 351(1), 21-25 (2006)
Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats.
Wang J
Endocrine, 33(1), 77-83 (2008)
Effect of Peripheral Obestatin Infusion on Serum Glucose and some Enzymatic Parameters in rats
Rad M N
Advances in Bioresearch, 7 (3), 38-41 (2016)
Effects of obestatin on energy balance and growth hormone secretion in rodents.
Nogueiras R
Endocrinology, 148(1), 21-26 (2007)

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