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M9149

Mepartricin

Name: Mepartricin
Brand: SIGMA

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About This Item

Número CAS:

11121-32-7

Número MDL:

MFCD00070325

Código UNSPSC:

51101500

ID de substância PubChem:

329818084

potência

3700 units Mepartricin per mg

cor

yellow to yellow with tan cast powder

solubilidade

DMF: 50 mg/mL, slightly hazy, red to red-brown

espectro de atividade do antibiótico

fungi

Modo de ação

cell wall synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COC(=O)C1C(O)CC2(O)CC(O)CC(O)CC(O)CC(O)CC(=O)CC(O)CC(=O)OC(C(C)CCC(O)CC(=O)c3ccc(N)cc3)C(C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\C(CC1O2)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

InChI

1S/C59H86N2O19/c1-35-17-15-13-11-9-7-5-6-8-10-12-14-16-18-47(78-58-55(73)53(61)54(72)37(3)77-58)32-50-52(57(74)76-4)49(70)34-59(75,80-50)33-46(68)29-44(66)27-42(64)25-41(63)26-43(65)28-45(67)31-51(71)79-56(35)36(2)19-24-40(62)30-48(69)38-20-22-39(60)23-21-38/h5-18,20-23,35-37,40-42,44-47,49-50,52-56,58,62-64,66-68,70,72-73,75H,19,24-34,60-61H2,1-4H3/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t35?,36?,37-,40?,41?,42?,44?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,58+,59?/m1/s1

chave InChI

GIDIUOCSTCGLRW-QJSPMWJNSA-N

Descrição geral

Chemical structure: macrolide

Aplicação

Mepartricin is a polyene antibacterial with antifungal and antiprotozoal activity. It is an Amphotericin B(AmB) analogue and has been used to study scrapie. It is used as an antibiotic supplement in cell culture.

Mepartricin is used in studies on sterol biosynthesis and bacterial cell membranes. It may be incorporated into liposomes

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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[Multicenter clinical study of the effects of once daily administration of mepartricin 150.000 U. in benign prostatic hypertrophy].

E Pisani

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, 67(4), 223-230 (1995-09-01)

The effects of partricin methyl ester, administered to 481 BPH patients at the dose of 150.000 U as a single administration at night for 90 days were studied in the course of a multicentre study. The favourable evolution of the

Effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic growth of the dorsolateral prostate and seminal vesicle in immature castrated rats.

Shuji Shakuto et al.

Scandinavian journal of urology and nephrology, 39(5), 358-365 (2005-11-01)

To investigate the effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic prostate and seminal vesicle (SV) growth in castrated rats. Immature rats aged 3 weeks were castrated and left untreated for 1 week. Then, 17beta-estradiol benzoate (E(2)-BA) was

[Mepartricin in BPH. A new dosage approach].

D Prezioso et al.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 48(2), 117-120 (1996-06-01)

The authors assessed the validity of a treatment with mepartricin in BPH at the dose of 150,000 U in a once-a-day evening administration for 6 months. The results from the controlled study were compared with those obtained in a homogeneous

Role of mepartricin in category III chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized prospective placebo-controlled trial.

Aldo Franco De Rose et al.

Urology, 63(1), 13-16 (2004-01-31)

To verify the efficacy of mepartricin versus placebo with regard to symptom improvement in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS) and to verify a relation between hormonal levels and clinical improvement in these patients. Twenty-six patients with

[Can mepartricin be considered an antiandrogenic drug?].

C Lubrano et al.

Minerva urologica e nefrologica = The Italian journal of urology and nephrology, 44(2), 113-116 (1992-04-01)

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