M5691
Anti-MAGI-1 antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
reatividade de espécies
rat
técnica(s)
microarray: suitable
western blot: 1:500 using rat brain extracts
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MAGI1(9223)
mouse ... Magi1(14924)
rat ... Cnksr3(308113)
Categorias relacionadas
Descrição geral
The MAGUK (Membrane Associated Guanylate kinase) family of proteins localize to regions of cell-cell contact, such as tight junctions in epithelial cells and synaptic junctions in neurons. In epithelia, membrane associated guanylate kinase, WW And PDZ domain containing 1 (MAGI-1) is localized at tight junctions and is expressed in three isoforms (MAGI-1a, MAGI-1b, and MAGI-1c). MAGI-1 was first identified in mouse as a protein interacting with K-RasB (Ras-like protein rasB).
Especificidade
Recognizes rat MAGI-1 by immunoblotting (approx. 170, 130, and 120 kDa) and does not cross react with MAGI-2 or MAGI-3.
Imunogênio
synthetic peptide corresponding to amino acids 282-296 of MAGI-1 with a carboxy terminal added cysteine residue conjugated to maleimide-activated KLH. The sequence is conserved in human and mouse.
Aplicação
Anti-MAGI-1 antibody produced in rabbit has been used in
- immunoblotting
- western blotting
- immunostaining
Ações bioquímicas/fisiológicas
Membrane associated guanylate kinase, WW And PDZ domain containing 1 (MAGI-1) interacts with β-catenin. Neuroepithelial cell-transforming gene 1(nNET1) and actin binding proteins act as binding partners of MAGI-1. Interestingly, MAGI-1c is present in nucleus, suggesting that MAGI-1 may participate in the transmission of regulatory signals from the cell surface to the nucleus.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23
Xu Z, et al.
The Journal of Neuroscience, 28(44), 11269-11276 (2008)
Binding of PDZ proteins to HPV E6 proteins does neither correlate with epidemiological risk classification nor with the immortalization of foreskin keratinocytes
Muench P, et al.
Virology, 387(2), 380-387 (2009)
MAGI-1: A Widely Expressed, Alternatively Spliced Tight Junction Protein
Dobrosotskaya IY, et al.
Biochemical and Biophysical Research Communications, 270(3), 903-909 (2000)
Jun-Ichi Abe et al.
JCI insight, 4(7) (2019-04-05)
The possible association between the membrane-associated guanylate kinase with inverted domain structure-1 (MAGI1) and inflammation has been suggested, but the molecular mechanisms underlying this link, especially during atherogenesis, remain unclear. In endothelial cells (ECs) exposed to disturbed flow (d-flow), p90
Shuqin Jia et al.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 29(1), 25-35 (2017-04-05)
To explore the association of membrane-associated guanylate kinase inverted 1 (MAGI1) with gastric cancer (GC) and the related molecular mechanisms. The reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry (IHC) were utilized to measure the MAGI1 expression level in GC tissues.
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