M5046
(±)-α-Methyl-(4-sulfonophenyl)glycine
Sinônimo(s):
MSPG
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About This Item
Fórmula empírica (Notação de Hill):
C9H11NO5S
Número CAS:
Peso molecular:
245.25
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CC(N)(C(O)=O)c1ccc(cc1)S(O)(=O)=O
InChI
1S/C9H11NO5S/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H,13,14,15)
chave InChI
MVDSFPIEJILRME-UHFFFAOYSA-N
Ações bioquímicas/fisiológicas
Antagonist at Group III metabotropic glutamate receptors.
Código de classe de armazenamento
13 - Non Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Ivana Pulić et al.
Journal of structural biology, 194(2), 147-155 (2016-02-13)
Flagellin component D (FlgD) participates in the assembly of flagella, helical tubular structures that provide motility in non-filamentous bacteria. FlgD guides and controls the polymerization of FlgE that builds the hook, a short curved and hollow cylinder that connects the
Ersin Yavas et al.
ACS chemical neuroscience, 8(2), 320-328 (2017-01-26)
The N-methyl-d-aspartate (NMDA) receptor antagonist, phencyclidine, induces behavioral changes in rodents mimicking symptoms of schizophrenia, possibly mediated through dysregulation of glutamatergic control of mesolimbic dopamine release. We tested the hypothesis that NMDA receptor activation modulates accumbens dopamine release, and that
D E Jane et al.
Neuropharmacology, 34(8), 851-856 (1995-08-01)
The depression of the monosynaptic excitation of neonatal rat motoneurones produced by the metabotropic glutamate receptor (mGluR) agonists (1S,3S)-1-aminocyclopentane-1, 3-dicarboxylate (ACPD) or L-2-amino-4-phosphonobutyrate (L-AP4) was antagonized by three novel phenylglycine analogues: (RS)-alpha-methyl-4-sulphonophenylglycine (MSPG), (RS)-alpha-methyl-4-phosphonophenylglycine (MPPG) and (RS)-alpha-methyl-4-tetrazolylphenylglycine (MTPG). The potencies
Lorenzo Caputi et al.
Nature chemical biology, 16(4), 383-386 (2020-02-19)
Cycloaddition reactions generate chemical complexity in a single step. Here we report the crystal structures of three homologous plant-derived cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids. These enzymes act on the same substrate, named angryline, to generate
J S Bedingfield et al.
European journal of pharmacology, 309(1), 71-78 (1996-08-01)
The metabotropic glutamate (mGlu) receptor antagonist properties of novel phenylglycine analogues were investigated in adult rat cortical slices (mGlu receptors negatively coupled to adenylyl cyclase), neonatal rat cortical slices and in cultured rat cerebellar granule cells (mGlu receptors coupled to
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