M1695
MAZ51
≥98% (HPLC), solid
Sinônimo(s):
3-(4-Dimethylaminonaphthalen-1-ylmethylene)-1,3-dihydroindol-2-one
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About This Item
Fórmula empírica (Notação de Hill):
C21H18N2O
Número CAS:
Peso molecular:
314.38
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
Ensaio
≥98% (HPLC)
forma
solid
cor
orange
solubilidade
DMSO: 11 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CN(C)c1ccc(\C=C2/C(=O)Nc3ccccc23)c4ccccc14
Ações bioquímicas/fisiológicas
Cell-permeable VEGFR-3 inhibitor. At low concentration ≥ 5 μM), it specifically blocks VEGF-C- and VEGF-D-induced phosphorylation of VEGFR-3, but not VEGFR-2, in PAE cells. It partially blocks VEGFR-2 phosphorylation only at higher concentrations (50 μM).
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
Certificados de análise (COA)
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Ji Yoon Lee et al.
Cancer letters, 354(2), 281-289 (2014-08-27)
Acute myeloid leukemia (AML) cells in vivo are constantly exposed to lymphangiogenic cytokines such as VEGF-C. However, it is poorly understood how the VEGF-C signaling modulates the immune functions in the tumor microenvironment. We have previously reported that natural killer
Jeffrey Harding et al.
The American journal of pathology, 185(2), 432-445 (2015-01-20)
Granulomatous inflammation is characteristic of many autoimmune and infectious diseases. The lymphatic drainage of these inflammatory sites remains poorly understood, despite an expanding understanding of lymphatic role in inflammation and disease. Here, we show that the lymph vessel growth factor
Jeong Ae Park et al.
PLoS genetics, 11(7), e1005324-e1005324 (2015-07-07)
Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail
Joo-Hee Park et al.
PloS one, 9(9), e109055-e109055 (2014-10-01)
MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape
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