Todas as fotos(1)

Documentos Principais

COO/COA

Visualizar Toda a Documentação

J2128

Anti-phospho-c-Jun (pSer⁶³) antibody produced in rabbit

Name: Anti-phospho-c-Jun (pSer<SUP>63</SUP>) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous glycerol solution

Faça loginpara ver os preços organizacionais e de contrato

Todas as fotos(1)

About This Item

Número MDL:

MFCD01092289

Código UNSPSC:

12352203

NACRES:

NA.41

fonte biológica

rabbit

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous glycerol solution

peso molecular

antigen 48 kDa

reatividade de espécies

rat, mouse, human

técnica(s)

flow cytometry: 1:200
microarray: suitable
western blot (chemiluminescent): 1:1,000 using extract of NIH3T3 anisomycin or UV-treated cells

nº de adesão UniProt

P05412

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pSer63)

Informações sobre genes

human ... JUN(3725)
mouse ... Jun(16476)

Especificidade

The antibody does not react with the corresponding phosphorylated form of JunD or JunB.

Imunogênio

synthetic phosphoserine⁶³ peptide corresponding to residues around Ser⁶³ of human c-Jun, conjugated to KLH.

Aplicação

Anti-phospho-c-Jun (pSer63) antibody produced in rabbit has been used in microarray analysis to identify the changes in the level of cellular proteins in cells inoculated with Equine influenza virus.

Ações bioquímicas/fisiológicas

The protooncogene c-Jun encodes a member of the jun family that forms a component of the transcription factor AP-1 (Activator Protein-1). It dimerizes with a member of the Fos family via the leucine-zipper motif to form AP-1, a factor involved in binding to TPA (12-O-tetradecanoylphorbol 13-acetate) response element (TRE) of various genes that include human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. The dimers formed are involved in the activation of AP-1 dependent genes. AP-1 regulates the transcription of mammalian DDI (DNA-damage-inducible) genes.

forma física

Solution in 10 mM HEPES sodium, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and 50% glycerol.

Não está encontrando o produto certo?

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Rapid and preferential activation of the c-jun gene during the mammalian UV response.

Y Devary et al.

Molecular and cellular biology, 11(5), 2804-2811 (1991-05-01)

Exposure of mammalian cells to DNA-damaging agents leads to activation of a genetic response known as the UV response. Because several previously identified UV-inducible genes contain AP-1 binding sites within their promoters, we investigated the induction of AP-1 activity by

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1.

P Angel et al.

Cell, 55(5), 875-885 (1988-12-02)

Binding of the human transcription factor Jun/AP-1 to a conserved 8 bp nucleotide sequence (TRE) is responsible for increased transcription of different cellular genes in response to tumor promoters, such as TPA, and serum factors. Enhanced Jun/AP-1 activity in TPA-stimulated

Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha.

D A Brenner et al.

Nature, 337(6208), 661-663 (1989-02-16)

Tumour necrosis factor-alpha (TNF-alpha) is secreted by macrophages in response to inflammation, infection and cancer. Sublethal doses of recombinant TNF-alpha to rats causes cachexia, anaemia and inflammation. TNF-alpha plays a major part in tissue inflammation and remodelling by stimulating production

jun-D: a third member of the jun gene family.

K Ryder et al.

Proceedings of the National Academy of Sciences of the United States of America, 86(5), 1500-1503 (1989-03-01)

The protooncogene c-jun encodes a component of the transcription factor AP-1. Both murine c-jun and a related gene (jun-B) are rapidly activated in BALB/c3T3 cells by serum growth factors. We report here the cloning and analysis of a cDNA encoding

Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism.

Michał Biernacki et al.

Advances in medical sciences, 64(1), 15-23 (2018-09-23)

The effect of chronic administration of [3-(3-carbamoylphenyl)phenyl] N-cyclohexylcarbamate (URB597), inhibitor of fatty acid amide hydrolase (FAAH) that hydrolyzes anandamide, on cross-talk between endocannabinoid system, oxidative status and pro-inflammatory factors in the liver of spontaneously hypertensive rats (SHRs) was investigated. Experiments

Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica