GW22840
Anti-ERP29 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
fonte biológica
chicken
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
rat, human
fabricante/nome comercial
Genway 15-288-22840
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... ERP29(10961)
Imunogênio
Immunogen Sequence: GI # 5803013, sequence 33-261
Recombinant endoplasmic reticulum protein 29 isoform 1
Aplicação
Anti-ERP29 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Ações bioquímicas/fisiológicas
Endoplasmic reticulum protein 29 (ERp29) is a chaperone protein encoded by the ERP29 gene in humans. It is a novel factor that can drive mesenchymal-epithelial transition (MET) and induce cell growth arrest in MDA-MB-231 cells. It regulates MET and epithelial cell integrity in breast cancer cells. ERp29 is an endoplasmic reticulum (ER) stress-inducible protein and is highly expressed in several cancers and associated with resistance to oxidative and radiation stress. It may act as a potential biomarker for predicting nasopharyngeal carcinoma (NPC) response to radiotherapy.[1] The molecule facilitates processing and transport of proteins in the early secretory pathway and its over-expression significantly inhibits proliferation and suppresses tumorigenesis by modulating ER stress signaling and the mesenchymal-epithelial transition in breast cancer cells.
forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Lin Qi et al.
Medical oncology (Northwood, London, England), 29(2), 721-728 (2011-04-12)
ERp29 is an endoplasmic reticulum (ER) stress-inducible protein. It was found that ERp29 was highly expressed in several cancers and associated with resistance to oxidative and radiation stress, which may serve as a novel target for nasopharyngeal carcinoma (NPC) anticancer
Daohai Zhang et al.
The international journal of biochemistry & cell biology, 43(1), 33-36 (2010-10-06)
The endoplasmic reticulum protein 29 (ERp29) is a molecule that facilitates processing and transport of proteins in the early secretory pathway. Structural and functional analyses have suggested a biological role as a putative chaperone in the endoplasmic reticulum. The N-terminal
Ping Wu et al.
Oncology reports, 27(4), 987-994 (2011-12-14)
Radioresistance continues to be a major problem in the treatment of nasopharyngeal carcinoma (NPC). This study aimed to identify novel proteins associated with NPC
I Fon Bambang et al.
Laboratory investigation; a journal of technical methods and pathology, 89(11), 1229-1242 (2009-09-23)
Endoplasmic reticulum protein 29 (ERp29) is a novel endoplasmic reticulum (ER) secretion factor that facilitates the transport of secretory proteins in the early secretory pathway. Recently, it was found to be overexpressed in several cancers; however, little is known regarding
I F Bambang et al.
Oncogene, 32(10), 1240-1251 (2012-05-01)
The epithelial-mesenchymal transition (EMT) correlates with disruption of cell-cell adhesion, loss of cell polarity and development of epithelial cell malignancy. Identifying novel molecules that inhibit EMT has profound potential for developing mechanism-based therapeutics. We previously demonstrated that the endoplasmic reticulum
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