GW22689B
Anti-MMP12 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
fonte biológica
chicken
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
técnica(s)
western blot: suitable
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... MMP12(4321)
Descrição geral
MMP12 (matrix metalloproteinase 12) is a member of the MMP protein family and is localized to human chromosome 11q22.2-22.3. It is made of nine introns and ten exons, and spans 13kb. It is expressed in a very narrow range of human tissues, and assay of multiple normal human tissues showed its mRNA expression only in placenta. It is found to be expressed in alveolar macrophages of cigarette smokers. It is also called macrophage metalloelastase, and is produced in an inactive form of 54kDa. It is cleaved into an active form of 45kDa, which if further cleaved into 22kDa form. Predominantly, it acts on elastin, and can also degrade fibronectin, laminin, vitronectin etc.
Imunogênio
Immunogen Sequence: GI # 4505207, sequence 107-470
Recombinant matrix metalloproteinase 12 preproprotein
Aplicação
Anti-MMP12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Ações bioquímicas/fisiológicas
Matrix metalloproteinase-12 (MMP-12) may act as a specific marker of Stanford-A acute aortic dissection (AAD). The gene is expressed in the primary tumor and acts as a molecular marker that may be useful for predicting extracapsular spread (ECS) in head and neck squamous cell carcinomas (HNSCC) patients with metastatic nodal disease. It may be associated with asthma through inappropriate attraction of leukocytes to the inflamed tissue. It may also serve as a potential diagnostic tool and a therapeutic target in vascular injury and repair.
forma física
Solution in phosphate buffered saline containing 0.02% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Maria Proietta et al.
Annals of medicine, 46(1), 44-48 (2014-01-18)
The study evaluated macrophage cytokines and macrophage metalloprotease (MMP)-12 levels in patients with Stanford-A acute aortic dissection (AAD) and in patients with critical carotid artery stenosis (CAS) compared with patients matched for age, sex, and traditional cardiovascular risk factors (RF).
Yi Song et al.
BMC cardiovascular disorders, 13, 34-34 (2013-05-07)
Aortic dissection(AD) is an acute process of large blood vessels characterized by dangerous pathogenic conditions and high disability and high mortality. The pathogenesis of AD remains debated. Matrix metalloproteinase-12 (MMP-12) participates in many pathological processes such as abdominal aortic aneurysm
A Belaaouaj et al.
The Journal of biological chemistry, 270(24), 14568-14575 (1995-06-16)
Human macrophage metalloelastase (HME) is a recent addition to the matrix metalloproteinase (MMP) family that was initially found to be expressed in alveolar macrophages of cigarette smokers. To understand more about HME expression, analysis of the structure and location of
Jin Man Kim et al.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 270(3), 1137-1142 (2012-08-22)
Matrix metalloproteinases (MMPs) play an important role in tumor invasiveness and metastasis. The aim of this study was to investigate the expression pattern of MMPs in the primary tumor of head and neck squamous cell carcinomas (HNSCC) with cervical node
Fumiya Yamaide et al.
International archives of allergy and immunology, 160(3), 287-296 (2012-10-19)
Matrix metalloproteinase 12 gene (MMP12) has been shown to be associated with asthma in a Caucasian population. In this study, we investigate whether single-nucleotide polymorphisms (SNPs) of MMP12 are associated with a risk for asthma in a Japanese population. We
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