GW22280A

Anti-KLHL12 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-C3IP1, Anti-DKIR
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: chicken
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• reatividade de espécies: human
• fabricante/nome comercial: Genway 15-288-22280A
• técnica(s): western blot: suitable
• nº de adesão NCBI: NP_067646.1
• nº de adesão UniProt: Q53G59
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... KLHL12(59349)

Descrição

Descrição geral

Kelch-like protein 12 is a novel human kelch protein localized to a ring canal structure. It consists of N-terminal POZ (poxviruses and zinc fingers) and intervening region (IVR) domains. It plays an important role in the ring-like structure activity during oocyte development.

Imunogênio

Immunogen Sequence: GI # 11056006, sequence 205-404

Recombinant kelch-like 12

Aplicação

Anti-KLHL12 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Ações bioquímicas/fisiológicas

Kelch-like protein 12 is a protein encoded by the KLHL12 gene in humans. It is a Bric à Brac (BTB)-Kelch protein and specifically binds to the polymorphic region of the D4 receptor through its Kelch domain. KLHL12 also interacts with Cullin3 and functions as an adaptor to target the D4 receptor to an E3 ubiquitin ligase complex. Its overexpression strongly promotes ubiquitination of the D4 receptor. KLHL12 is essential for the development of the ring-like structure, which is independent of the ability to bind actin. It interacts with both immature, ER-associated and mature, plasma membrane-associated D4 receptors, β-arrestin2, and also promotes ubiquitination of both receptor subpools.

forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)