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GW21035

Sigma-Aldrich

Anti-MIP-1β antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-Chemokine C-C motif ligand 4 isoform 1, Anti-Macrophage inflammatory protein 1β, Anti-SCYA4, Anti-Small inducible cytokine A4

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
ELISA (i)
WB
clone:
polyclonal
reatividade de espécies:
human
citations:
5
técnica(s):
indirect ELISA: suitable
western blot: suitable

fonte biológica

chicken

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

Formulário

buffered aqueous solution

reatividade de espécies

human

fabricante/nome comercial

Genway 15-288-21035

técnica(s)

indirect ELISA: suitable
western blot: suitable

nº de adesão NCBI

NP_002975.1

nº de adesão UniProt

P13236

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... CCL4(6351)

Descrição geral

MIP-1β (macrophage inflammatory protein 1β) is a member of the CC chemokine (cysteine-cysteine) family, and is produced by monocytes and macrophages. This protein exists as a homodimer. It acts as a ligand to the GPCR (G-protein coupled receptor) called CCR5 (CC chemokine receptor 5).

Imunogênio

Immunogen Sequence: GI # 4506845, sequence 27-92
Recombinant chemokine C-C motif ligand 4 isoform 1

Aplicação

Anti-MIP-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Ações bioquímicas/fisiológicas

Chemokine (C-C motif) ligand 4 (CCL4) is a principal regulator of macrophage migration and signals through CCR5. CCR5 is linked to several protein kinases including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2 and members of the MAPK family that help in regulating macrophage chemotaxis. CCL4 is released at the site of inflammation in sarcoidosis.

forma física

Solution in phosphate buffered saline containing 0.02% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
039K1757
029K1911

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Visite a Biblioteca de Documentos

A Barczyk et al.
International journal of immunopathology and pharmacology, 27(2), 185-193 (2014-07-10)
Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis
Melissa A McCornack et al.
The Journal of biological chemistry, 278(3), 1946-1956 (2002-11-02)
Chemokines comprise a family of proteins that function in the immune response to recruit leukocytes to sites of infection. This recruitment is believed to be carried out by the establishment of a chemokine gradient by the binding of chemokines to
Ricky Cheung et al.
Journal of leukocyte biology, 86(4), 833-845 (2009-07-22)
MIP-1beta/CCL4 is a principal regulator of macrophage migration and signals through CCR5. Several protein kinases are linked to CCR5 in macrophages including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2, and members of the MAPK family, but whether
Li Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(38), 13985-13990 (2006-09-12)
Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high
Isaac G Sakala et al.
Infection and immunity, 81(6), 1974-1983 (2013-03-20)
Tuberculosis remains one of the top three leading causes of morbidity and mortality worldwide, complicated by the emergence of drug-resistant Mycobacterium tuberculosis strains and high rates of HIV coinfection. It is important to develop new antimycobacterial drugs and immunomodulatory therapeutics

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