peptide corresponding to the human GLUT10 protein (amino acids 367-385).
Ações bioquímicas/fisiológicas
GLUT10 is a glucose transporter that is encoded by the gene SLC2A10, and is highly expressed in liver and pancreas. Polymorphisms in SLC2A10 may not influence the pathogenesis of type 2 diabetes but the expression of GLUT10 and the interaction with TGF-β signaling pathway has important role in the development of peripheral arterial disease in patients with type 2 diabetes. GLUT10 is also required for the development of cardiovascular system and the notochord in zebrafish embryos.
forma física
Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.
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The SLC2A10 gene encodes the GLUT10 facilitative glucose transporter, which is expressed in high amounts in liver and pancreas. The gene is mapped to chromosome 20q12-q13.1, a region that has been shown to be linked to type 2 diabetes. The
Human molecular genetics, 21(6), 1248-1259 (2011-11-26)
Growth factor signaling results in dramatic phenotypic changes in cells, which require commensurate alterations in cellular metabolism. Mutations in SLC2A10/GLUT10, a member of the facilitative glucose transporter family, are associated with altered transforming growth factor-β (TGFβ) signaling in patients with
Recent data indicate that loss-of-function mutation in the gene encoding the facilitative glucose transporter GLUT10 (SLC2A10) causes arterial tortuosity syndrome via upregulation of the TGF-β pathway in the arterial wall, a mechanism possibly causing vascular changes in diabetes. We genotyped
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