F7926
Anti-phospho-FAK (pTyr397) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Sinônimo(s):
Anti-phospho-Focal Adhesion Kinase
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About This Item
Número MDL:
Código UNSPSC:
12352203
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous glycerol solution
uso
sufficient for 10 blots
reatividade de espécies
human, rat, mouse, Drosophila, frog
técnica(s)
western blot: 1:1,000
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... PTK2(5747)
Descrição geral
Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle[1][2]. Anti-phospho-FAK (pTyr397) antibody can be used in immunocytochemistry and immunohistochemistry. Rabbit anti- phospho-FAK (pTyr397) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 397. This product can also react with FAK (pTyr397) of rat, chicken, frog, mouse and human.
Imunogênio
synthetic phophopeptide derived from the region of FAK that contains tyrosine 397.
Aplicação
Anti-phospho-FAK (pTyr397) antibody can be used in immunoblotting (diluted 1:1000) and microarray.
forma física
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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J M Taylor et al.
The Journal of biological chemistry, 275(25), 19250-19257 (2000-04-06)
A variety of agonists including phenylephrine (PE) induce hypertrophy in neonatal ventricular cardiomyocytes. Here we report that signals provided by extracellular matrix proteins (ECM) augment the PE-induced hypertrophic response of cardiomyocytes and provide evidence that ECM-dependent signaling is mediated in
J D Owen et al.
Molecular and cellular biology, 19(7), 4806-4818 (1999-06-22)
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is
Sean E Gill et al.
Developmental biology, 298(2), 540-554 (2006-08-08)
Tissue inhibitors of metalloproteinases (TIMPs) regulate extracellular matrix (ECM) degradation by matrix metalloproteinases (MMPs) throughout embryogenesis. We examined lungs from TIMP3 null mice and found decreased bronchiole branching, enhanced activity of MMPs and enhanced fibronectin degradation throughout lung development compared
Potential roles for focal adhesion kinase in development.
Ridyard MS, Sanders EJ
Anat. Embryol., 199(1), 1-7 (1999)
Xuelian Tang et al.
Cancer biology & therapy, 5(11), 1474-1480 (2006-10-03)
Herein, we report that marine-derived sulfated polysaccharide (MSP), a new kind of polysaccharide extracted from brown alga, exhibits the anti-migration effect in vitro and potently suppress metastasis of Lewis lung carcinoma in vivo. Adhesion assays demonstrated that MSP inhibits the
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