E7528

Anti-S1P₅, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

• Sinônimo(s): Anti-EDG-8, Anti-Endothelial Cell Differentiation Gene 8
• Número MDL: MFCD03454973
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 200
• conjugado: unconjugated
• forma do anticorpo: fractionated antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~42 kDa by SDS-PAGE
• reatividade de espécies: human
• concentração: ~1 mg/mL
• técnica(s): western blot: suitable
• nº de adesão UniProt: Q9H228
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... S1PR5(53637)

Descrição

Imunogênio

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-8/S1P₅ receptor.

Aplicação

Anti-S1P₅, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using RH7777 cells transfected with full length human EDG-8.

Ações bioquímicas/fisiológicas

Sphingosine-1-phosphate receptor 5 (S1PR5) is a human gene which encodes a G protein-coupled receptor. It binds to lipid signaling molecule sphingosine 1-phosphate (S1P). S1PR5 regulates NK cell migration and distribution by interacting with sphingosine-1-phosphate (S1P). In brain endothelial cells (ECs), it contributes to optimal barrier formation and maintains immune quiescence of the barrier endothelium. S1PR5 is localized in the centrosome of mammalian cells and may participate in regulating mitosis. It may function as an intracellular target of S1P linked to regulation of mitosis.

forma física

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids