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D7250

Sigma-Aldrich

2′-Deoxycytidine 5′-diphosphate sodium salt

≥96%

Sinônimo(s):

dCDP

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About This Item

Fórmula empírica (Notação de Hill):
C9H15N3O10P2 · xNa+
Número CAS:
151151-32-5
Peso molecular:
387.18 (free acid basis)
Número MDL:
MFCD00056068
Código UNSPSC:
41106305
ID de substância PubChem:
24894092
NACRES:
NA.51

Ensaio

≥96%

forma

powder

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.[Na].NC1=NC(=O)N(C=C1)C2CC(O)C(COP(O)(=O)OP(O)(O)=O)O2

InChI

1S/C9H15N3O10P2.Na.H2O.H/c10-7-1-2-12(9(14)11-7)8-3-5(13)6(21-8)4-20-24(18,19)22-23(15,16)17;;;/h1-2,5-6,8,13H,3-4H2,(H,18,19)(H2,10,11,14)(H2,15,16,17);;1H2;

chave InChI

MNOALMYIRLFAQW-UHFFFAOYSA-N

Categorias relacionadas

Aplicação

2′-Deoxycytidine 5′-diphosphate (dCDP) has been used as a substrate for nucleotide diphosphate kinase (NDPK) to produce 2′-deoxycytidine 5′-triphosphate (dCTP) in support of DNA biosynthesis and reverse transcription.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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High glucose triggers nucleotide imbalance through O-GlcNAcylation of key enzymes and induces KRAS mutation in pancreatic cells
Hu CM, et al.
Cell Metabolism, 29(6), 1334-1349 (2019)
Hüseyin Besir et al.
FEBS letters, 579(29), 6595-6600 (2005-11-19)
Nucleoside diphosphate kinase from the halophilic archaeon Halobacterium salinarum was crystallized in a free state and a substrate-bound form with CDP. The structures were solved to a resolution of 2.35 and 2.2A, respectively. Crystals with the apo-form were obtained with
Argirios Siskos et al.
Journal of plant physiology, 167(9), 675-682 (2010-03-02)
Two isoforms of NDPKs (diphosphonucleoside kinases: E.C. 2.7.4.6.) named S-NDPK-A and S-NDPK-B were separated and purified from shoots of Alyssum murale (19th day of growth), a nickel accumulator plant, by a four-step procedure involving ammonium sulphate precipitation and DEAE-sepharose and
Mahmoud Kandeel et al.
Journal of bioenergetics and biomembranes, 42(5), 361-369 (2010-08-17)
Nucleoside diphosphate kinases (NDKs) play a key role in maintaining the intracellular energy resources as well as the balance of nucleotide pools. Recently, attention has been directed to NDKs owing to its role in activating various chemotherapeutic agents. The binding
Dimitri Topalis et al.
Nucleosides, nucleotides & nucleic acids, 26(10-12), 1369-1373 (2007-12-11)
Human UMP-CMP kinase is involved in the phosphorylation of nucleic acid precursors and also in the activation of antiviral analogues including cidofovir, an acyclic phosphonate compound that mimicks dCMP and shows a broad antiviral spectrum. The binding of ligands to
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