Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

D144

Sigma-Aldrich

DALDA

>96%, solid

Sinônimo(s):

[D-Arg2, Lys4]-Dermorphin-(1-4)-amide

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Fórmula empírica (Notação de Hill):
C30H44N8O6
Número CAS:
118476-85-0
Peso molecular:
612.72
Número MDL:
MFCD00144042
Código UNSPSC:
12352200
ID de substância PubChem:
24893439

Ensaio

>96%

forma

solid

cor

white

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NCCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C(CCCNC(N)=N)NC(=O)C(N)Cc2ccc(O)cc2)C(N)=O

Procurando produtos similares? Visita Guia de comparação de produtos

Amino Acid Sequence

Tyr-D-Arg-Phe-Lys-NH2

Ações bioquímicas/fisiológicas

Highly selective μ opioid receptor agonist.

Código de classe de armazenamento

8B - Non-combustible corrosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Damien J Keating et al.
The Journal of physiology, 555(Pt 2), 489-502 (2004-01-16)
Before the preganglionic regulation of the adrenal medulla is established, hypoxia acts directly on the chromaffin cells to evoke the secretion of catecholamines. This direct action of hypoxia is suppressed by the gradual development of the preganglionic innervation and we
Guo-Min Zhao et al.
The Journal of pharmacology and experimental therapeutics, 302(1), 188-196 (2002-06-18)
Recent studies suggest that delta-opioid receptors play a role in the development of opioid tolerance and led us to hypothesize that highly selective mu-opioid agonists may produce less tolerance. H-2',6'-dimethyltyrosine-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA) has extraordinary selectivity for mu-receptors (K(i)(delta)/K(i)(mu) > 14,000). Daily
Yong Ben et al.
British journal of pharmacology, 143(8), 987-993 (2004-11-24)
Previously, we reported that H-2',6'-dimethyltyrosine [Dmt(1)]-d-Arg-Phe-Lys-NH(2) (DALDA), an analogue of the naturally occurring opioid peptide dermorphin, is a highly potent and selective mu receptor agonist with low cross-tolerance to morphine. In the present study, we investigated the effect of treating
Pal Riba et al.
Current medicinal chemistry, 9(1), 31-39 (2002-02-28)
The clinical effectiveness of morphine is limited by several side effects, including the development of tolerance and dependence. Most of these side effects are believed to be mediated by central opioid receptors; therefore, hydrophilic opioids, which don't cross the blood-brain
Claire L Neilan et al.
The Journal of pharmacology and experimental therapeutics, 306(2), 430-436 (2003-03-29)
The dermorphin-derived peptide [Dmt1]DALDA (H-Dmt-d-Arg-Phe-Lys-NH2; Dmt, 2',6'-dimethyltyrosine) labels mu-opioid receptors with high affinity and selectivity in receptor binding assays. In previous studies, [Dmt1]DALDA displayed a mechanism of action distinct from that of morphine, as evidenced by its insensitivity to antisense
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica