C8239
Anti-α-N-Catenin antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
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About This Item
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 102 kDa
reatividade de espécies
mouse
técnica(s)
microarray: suitable
western blot: 1:1,000 using cytosolic fraction of mouse brain
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
mouse ... Ctnna2(12386)
Descrição geral
The catenins (α, β, γ) are cytoplasmic proteins found in varying developing and adult tissues. α- N-catenin is a cadherin-binding protein, that plays a crucial role in cadherin-mediated cell-cell adhesion. It is widely expressed in the nervous system. α-Catenin (CAP102, 102 kDa), originally described as an E-cadherin associated protein, has been shown to associate with N-cadherin and P-cadherin. Within its conserved region α-catenin shows 30% identity to vinculin. There are at least two subtypes of α-catenin: α-E-catenin and α-N-catenin (102 kDa). The predominant form is α-E-catenin. Alternative spliced forms of α-N-catenin include α-N-catenin I and α-N-catenin II. The ratio of the two isoforms changes during development: isoforms II is more abundant than isoform I in early embryonic development, whereas isoform I is predominant in the adult stage.
Imunogênio
synthetic peptide corresponding to a region located near the N-terminus of human α-N-catenin (amino acids 171-186) conjugated to KLH. This sequence is identical in mouse and chicken α-N-catenin. It is not found in α-E-catenin, β-catenin, and γ-catenin.
Aplicação
α-N-Catenin antibody is suitable for microarray and western blot at a dilution of 1:1,000 by using cytosolic fraction of mouse brain.
Ações bioquímicas/fisiológicas
Catenins bind directly or indirectly to the conserved cytoplasmic tail domain of the cell adhesion cadherins. The association of catenins to cadherins produces a complex, which is linked to the actin filament network. Catenins/cadherin complexes play an important role in mediating cell adhesion, transduction of cell-cell contact positional signals to the cell interior, and may play a crucial role in cell differentiation. The expression of α-N-catenin is more restricted and this form predominates in the brain and is localized at synaptic junctions.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Unraveling the cytoplasmic interactions of the cadherin superfamily.
P Cowin
Proceedings of the National Academy of Sciences of the United States of America, 91(23), 10759-10761 (1994-11-08)
Masato Uemura et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 235(9), 2559-2566 (2006-05-13)
Alpha N-catenin is a cadherin-binding protein, widely expressed in the nervous system; and it plays a crucial role in cadherin-mediated cell-cell adhesion. Here we report the effects of alpha N-catenin gene deficiency on brain morphogenesis. In addition to the previously
D L Rimm et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(19), 8813-8817 (1995-09-12)
Calcium-dependent homotypic cell-cell adhesion, mediated by molecules such as E-cadherin, guides the establishment of classical epithelial cell polarity and contributes to the control of migration, growth, and differentiation. These actions involve additional proteins, including alpha- and beta-catenin (or plakoglobin) and
N Uchida et al.
Developmental biology, 163(1), 75-85 (1994-05-01)
We isolated cDNAs encoding mouse homologues of chicken alpha N-catenin, a protein associated with the cadherin cell adhesion molecules, and identified two isoforms of this protein. One isoform (alpha N-catenin I) was identical to the chicken alpha N-catenin that had
N Uchida et al.
The Journal of cell biology, 135(3), 767-779 (1996-11-01)
Molecular mechanisms linking pre- and postsynaptic membranes at the interneuronal synapses are little known. We tested the cadherin adhesion system for its localization in synapses of mouse and chick brains. We found that two classes of cadherin-associated proteins, alpha N-
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