C7740
Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
fonte biológica
rabbit
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
lyophilized powder
reatividade de espécies
rat, bovine, human, mouse
técnica(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL
indirect immunofluorescence: 5 μg/mL
western blot: 0.5 μg/mL using human cell extract
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
phosphorylation (pSer19)
Informações sobre genes
human ... CRYAB(1410)
mouse ... Cryab(12955)
rat ... Cryab(25420)
Especificidade
Does not detect the unphosphorylated protein.
Imunogênio
synthetic phosphopeptide surrounding the region of human α-B crystallin that contains serine 19.
Aplicação
Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit
- Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL
- Indirect immunofluorescence at a concentration of 5μg/mL
- Western blotting at a concentration of 0.5μg/mL using human cell extract
- It also used in 1- and 2-D immune blotting analysis.
Ações bioquímicas/fisiológicas
α-Crystallin B chain is a protein encoded by the CRYAB gene in humans. αB-crystallin (ABC) and HSP27 are most abundant in human tissues. It is predominantly expressed in triple-negative breast cancer (TNBC) and leads to aggressive tumor phenotype. αB-crystallin expression is primary found in breast carcinomas and brain metastases. αB-crystallin is overexpressed or silenced in two different TNBC cell lines. It is a novel regulator of brain metastasis in TNBC and acts as a potential biomarker for drug target in aggressive disease. αB-crystallin and VEGF expressions in human conjunctival squamous cell carcinoma (CSCCs) may play an important role in the pathogenesis. Mutation in the gene is responsible for a number of inherited human disorders, which include cardiomyopathy, skeletal muscle myopathy and cataracts.
forma física
Lyophilized from phosphate buffered saline, pH 7.4, containing 3% bovine serum albumin and 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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produto relacionado
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Bimal Prasanna Mohanty et al.
Indian journal of biochemistry & biophysics, 48(1), 35-41 (2011-04-08)
Crystallins are a diverse group of proteins that constitute nearly 90% of the total soluble proteins of the vertebrate eye lens and these tightly packed crystallins are responsible for transparency of the lens. These proteins have been studied in different
Zhenyu Dong et al.
Anticancer research, 33(9), 3745-3751 (2013-09-12)
To examine the expression of αB-crystallin and vascular endothelial growth factor (VEGF) in conjunctival squamous cell carcinoma (CSCC). Seven CSCCs and three normal conjunctivas that were surgically excised were studied. Paraformaldehyde-fixed, paraffin-embedded tissue sections were processed for immunohistochemistry with antibodies
Shuji Ueda et al.
International journal of molecular sciences, 23(19) (2022-10-15)
Protein homeostasis, including protein folding, refolding, and degradation, is thought to decline with aging. HSPB5 (also known as αB-crystallin) prevents target protein aggregation as a molecular chaperone and exhibits a cytoprotective function against various cell stresses. To elucidate the effect
Dmitry Malin et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(1), 56-67 (2013-10-18)
Basal-like breast tumors are typically (ER/PR/HER2) triple-negative and are associated with a high incidence of brain metastases and poor clinical outcomes. The molecular chaperone αB-crystallin is predominantly expressed in triple-negative breast cancer (TNBC) and contributes to an aggressive tumor phenotype
Heng B Xie et al.
PLoS genetics, 9(6), e1003544-e1003544 (2013-07-03)
Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts. The cellular mechanisms of disease pathology for these disorders are not well understood. Among recent advances
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