C7291

Clomipramine hydrochloride

≥98% (HPLC), powder

• Sinônimo(s): 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride, Anafranil hydrochloride
• Fórmula empírica (Notação de Hill): C₁₉H₂₃ClN₂ · HCl
• Número CAS: 17321-77-6
• Peso molecular: 351.31
• Número CE: 241-344-3
• Número MDL: MFCD00069234
• Código UNSPSC: 12352116
• ID de substância PubChem: 24278087
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• cor: white to off-white
• solubilidade: H₂O: 25 mg/mL; 0.1 M HCl: soluble
• originador: Novartis
• cadeia de caracteres SMILES: Cl.CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13
• InChI: 1S/C19H23ClN2.ClH/c1-21(2)12-5-13-22-18-7-4-3-6-15(18)8-9-16-10-11-17(20)14-19(16)22;/h3-4,6-7,10-11,14H,5,8-9,12-13H2,1-2H3;1H
• chave InChI: WIMWMKZEIBHDTH-UHFFFAOYSA-N
• Informações sobre genes: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrição

Descrição geral

Clomipramine hydrochloride is an antiobsessional drug. It has anticholinergic activity in vitro and in vivo. Clomipramine is used to treat obsessive compulsive disorder and panic disorder.

Aplicação

Clomipramine hydrochloride has been used to manipulate serotonin (5-HT) mechanisms. It has also been used to study its role on bone mass.

Clomipramine hydrochloride has been used:

• to study its effect on human serum albumin using UV-visible, fluorescence and circular dichroism (CD) techniques
• to block itchy E3 ubiquitin protein ligase (ITCH) ubiquitin transthiolation
• as a serotonin reuptake inhibitor
• as a homologous to E6AP C terminus (HECT) E3 ligase inhibitor

Ações bioquímicas/fisiológicas

Clomipramine hydrochloride (CLP) is a amphiphilic drug, with two benzene rings in its structure. It exhibits anti-depressant property by restoring the equilibrium of certain natural materials in the human being. CLP acts as a potential therapeutic for obsessive compulsive disorder.

Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.

Características e benefícios

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08,GHS07,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H302,H336,H370,H410
• Declarações de precaução: P260 - P264 - P271 - P273 - P301 + P312 - P308 + P311
• Classificações de perigo: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 1 - STOT SE 3
• Órgãos-alvo: Central nervous system, Central nervous system,Cardiovascular
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves