C4871
Anti-CTGF (181-195) antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Sinônimo(s):
Anti-CCN2, Anti-Connective tissue growth factor precursor isoform 1, Anti-HCS24, Anti-IGFBP8
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
conjugado:
unconjugated
application:
WB
clone:
polyclonal
reatividade de espécies:
human
citations:
5
técnica(s):
western blot: 1:500-1:2,000
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
IgG fraction of antiserum
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen ~38 kDa
reatividade de espécies
human
técnica(s)
western blot: 1:500-1:2,000
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CTGF(1490)
Descrição geral
Connective tissue growth factor (CTGF) is a secreted multimodular protein, which is an important cytokine, belonging to the CCN family of multifunctional factors.
Imunogênio
synthetic peptide corresponding to amino acids 181-195 of human CTGF
Aplicação
Anti-CTGF (181-195) antibody produced in rabbit has been used in immunoblot assay to study the protein expression of cells and renal tissues. It is also suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Ações bioquímicas/fisiológicas
Connective tissue growth factor (CTGF) is involved in several developmental regulatory processes of chondrogenesis, osteogenesis, and angiogenesis. It also has implications in various pathologcal processes, including, fibrosis, and tumorigenesis. Its gene expression is sensitive to DNA methylation. The methylation of the CTGF promoter is correlated with CTGF expression in ovarian cancer cells and may be involved in liver tumorigenesis. Its C-terminal domain plays a vital role in the S1P (sphingosine-1-phosphate)-induced endothelial cell migration.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Hao Zhang et al.
Molecular medicine reports, 9(6), 2138-2144 (2014-03-29)
Increasing evidence shows that DNA methylation is involved in the development and progression of diabetes mellitus (DM) and its complications. Previous studies conducted by our group have indicated that high glucose levels may induce the demethylation process of the connective
Margaret Markiewicz et al.
Microcirculation (New York, N.Y. : 1994), 18(1), 1-11 (2010-12-21)
The primary objective of this study was to examine the potential interaction between S1P, a pleiotropic lipid mediator, and CTGF/CCN2, a secreted multimodular protein, in the process of endothelial cell migration. The secondary objective was to determine whether C- and
Francisco V Souza-Neto et al.
Antioxidants (Basel, Switzerland), 11(7) (2022-07-28)
We have evaluated cardiac function and fibrosis in infarcted male Wistar rats treated with MitoQ (50 mg/kg/day) or vehicle for 4 weeks. A cohort of patients admitted with a first episode of acute MI were also analyzed with cardiac magnetic
Siao-Syun Guan et al.
Scientific reports, 5, 14561-14561 (2015-10-10)
In this study, we investigated the role of ATP synthase subunit-β (ATP5b) in diabetic nephropathy. Histopathological changes, fibrosis, and protein expressions of α-smooth muscle actin (α-SMA), advanced glycation end-products (AGEs), and ATP5b were obviously observed in the kidneys of db/db
Christoph Buken et al.
Scientific reports, 9(1), 11882-11882 (2019-08-17)
The literature suggests morphological alterations and molecular biological changes within the cellular milieu of human cells, exposed to microgravity (µg), as many cell types assemble to multicellular spheroids (MCS). In this study we investigated juvenile normal human dermal fibroblasts (NHDF)
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