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C0817

Sigma-Aldrich

Monoclonal Anti-HLA-DQ antibody produced in mouse

clone HK19, purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

Monoclonal Anti-HLA-DQ

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About This Item

Código UNSPSC:
12352203

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

HK19, monoclonal

forma

buffered aqueous solution

reatividade de espécies

human

técnica(s)

flow cytometry: 5 μL using 1 × 106 cells

Isotipo

IgG2b

nº de adesão UniProt

P01920

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HLA-DQB1(3119)

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Especificidade

Recognizes MHC Class II molecules that are preferentially expressed on the surface of B lymphocytes. The antibody reacts weakly with resting or ConA-activated T cells, monocytes, granulocytes, and erythrocytes.

Imunogênio

GM-1500 human tumor cell line.

Aplicação

Monoclonal Anti-HLA-DQ antibody produced in mouse is suitable for flow cytometry at a concentration of 5 μL using 1 × 106 cells.

Ações bioquímicas/fisiológicas

Human leukocyte antigen (HLA)-DQ is a cell surface receptor type protein found on antigen presenting cells. DQ is a αβ heterodimer of the MHC Class II type. It plays a central role in the immune system and is expressed in antigen presenting cells. HLA-DQ expression in cystic fibrosis CF is associated with inflammation and reduces response to Interferon γ (IFNγ). HLA-DQ acts as alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA) and antibody-mediated-rejection but does not support organ transplantation.

Descrição-alvo

HLA-DQ molecules are bimolecular glycoprotein complexes of 29 kDa and 33 kDa components. The HLA-DQ antigens are present on peripheral blood lymphocytes and tonsillar and splenic mononuclear cells.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

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Thomas P Hofer et al.
Journal of molecular medicine (Berlin, Germany), 92(12), 1293-1304 (2014-08-26)
We studied HLA class II molecules on blood monocyte subsets, blood dendritic cells, sputum macrophages, and monocyte-derived macrophages at the protein (flow cytometry) and mRNA level (RT-PCR) in adult patients with cystic fibrosis (CF) and healthy control subjects as putative
Anat R Tambur et al.
Transplantation, 98(2), 157-166 (2014-07-09)
Human leukocyte antigen (HLA)-DQ has emerged as the alloantibody most frequently associated with the generation of de novo donor-specific antibody (DSA), antibody-mediated-rejection, and unfavorable transplantation outcome. The generation of HLA-DQ de novo DSA was interrogated in 40 transplant recipients who
Rita-Désirée Jores et al.
Scandinavian journal of gastroenterology, 42(1), 48-53 (2006-12-28)
Celiac disease (CD) is a T-lymphocyte-mediated small intestinal enteropathy triggered and maintained by dietary gluten, with a strong genetic component mapping to the HLA genes encoding for the class II DQ(alpha1*0501, beta1*02) molecule. Damage of the small intestine may cause

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