BM0015

BMS-309403

≥98% (HPLC)

• Sinônimo(s): 2-[[2′-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1′-biphenyl]-3-yl]oxy]acetic acid, BMS 309403
• Fórmula empírica (Notação de Hill): C₃₁H₂₆N₂O₃
• Número CAS: 300657-03-8
• Peso molecular: 474.55
• Número MDL: MFCD09991687
• Código UNSPSC: 12352200
• ID de substância PubChem: 329774359
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 10 mg/mL, clear
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: O=C(O)COC1=CC(C2=CC=CC=C2N3C(CC)=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=N3)=CC=C1

Descrição

Ações bioquímicas/fisiológicas

BMS-309403 is a potent and selective inhibitor of fatty acid binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP, aP2). FABP4 is an intracellular lipid-binding protein responsible for the transportation of fatty acids. It is expressed primarily in adipose tissue and is associated with inflammation, obesity, diabetes and cardiovascular diseases. BMS309403 interacts with the fatty-acid-binding pocket within the interior of FABP4 and has been shown to competitively inhibit fatty acid binding with a Ki value < 2 nM. BMS309403 is orally active and has been shown to reduce atherosclerosis in mice studies.

BMS-309403 is a potent and selective inhibitor of fatty acid binding protein 4 (FABP4).

Características e benefícios

BMS-309403 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Informações legais

Sold for research purposes only under agreement from BMS.

Informações de segurança

• Código de classe de armazenamento: 13 - Non Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable