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B4056

Sigma-Aldrich

Bisindolylmaleimide XI hydrochloride

≥98% (TLC), solid

Sinônimo(s):

Ro 32-0432

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About This Item

Fórmula empírica (Notação de Hill):
C28H28N4O2 · HCl
Peso molecular:
489.01
Número MDL:
MFCD01319127
Código UNSPSC:
12352111
ID de substância PubChem:
329773227
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥98% (TLC)

forma

solid

solubilidade

DMSO: soluble

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.CN(C)CC1CCn2c(C1)cc3ccc(cc23)C4=C(C(=O)NC4=O)c5cn(C)c6ccccc56

InChI

1S/C28H28N4O2.ClH/c1-30(2)15-17-10-11-32-20(12-17)13-18-8-9-19(14-24(18)32)25-26(28(34)29-27(25)33)22-16-31(3)23-7-5-4-6-21(22)23;/h4-9,13-14,16-17H,10-12,15H2,1-3H3,(H,29,33,34);1H

chave InChI

WMVQGKBSNAIMHI-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

Selective inhibitor of protein kinase C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Guillaume Robert et al.
PloS one, 4(11), e7889-e7889 (2009-11-20)
CML is an hematopoietic stem cell disease characterized by the t(9;22) (q34;q11) translocation encoding the oncoprotein p210BCR-ABL. The effect of acadesine (AICAR, 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) a compound with known antileukemic effect on B cell chronic lymphoblastic leukemia (B-CLL) was investigated in different
Caline S Karam et al.
Journal of chemical neuroanatomy, 83-84, 91-98 (2017-06-03)
The dopamine transporter (DAT), which mediates the inactivation of released dopamine through its reuptake, is the primary molecular target for the actions of psychostimulants. An increasing number of studies support an essential role for phosphorylation of serines (Ser) in the
M Signore et al.
Cell death & disease, 5, e1223-e1223 (2014-05-09)
Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs)
Florence P Varodayan et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(17), 4593-4603 (2017-04-02)
L-type voltage-gated calcium channels (LTCCs) are implicated in several psychiatric disorders that are comorbid with alcoholism and involve amygdala dysfunction. Within the amygdala, the central nucleus (CeA) is critical in acute alcohol's reinforcing actions, and its dysregulation in human alcoholics
S Khom et al.
Science advances, 6(12), eaaz1050-eaaz1050 (2020-03-25)
Behavioral and clinical studies suggest a critical role of substance P (SP)/neurokinin-1 receptor (NK-1R) signaling in alcohol dependence. Here, we examined regulation of GABA transmission in the medial subdivision of the central amygdala (CeM) by the SP/NK-1R system, and its
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