AV38613

Anti-NFIL3 antibody produced in rabbit

IgG fraction of antiserum

• Sinônimo(s): Anti-Nuclear factor, interleukin 3 regulated
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• conjugado: unconjugated
• forma do anticorpo: IgG fraction of antiserum
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: 51 kDa
• reatividade de espécies: human
• concentração: 0.5 mg - 1 mg/mL
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• nº de adesão NCBI: NP_005375
• nº de adesão UniProt: Q14211
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... NFIL3(4783)

Descrição

Descrição geral

Nuclear factor, interleukin 3 regulated (NFIL3, E4BP4) is a transcription factor involved in development of haematopoietic lineages. NFIL3/E4BP4 is required for development of NK cells and CD8α(+) conventional dendritic cells, and myeloid lineage commitment. NFIL3/E4BP4 also facilitates macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE.

Especificidade

Anti-NFIL3 polyclonal antibody reacts with human, bovine, and canine nuclear factor, interleukin 3 regulated proteins.

Imunogênio

Synthetic peptide directed towards the N terminal region of human NFIL3

Aplicação

Anti-NFIL3 polyclonal antibody is used to tag nuclear factor, interleukin 3 regulated for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of nuclear factor, interleukin 3 regulated in haematopoietic lineages development and specialized immune function regulation.

Ações bioquímicas/fisiológicas

NFIL3 is a basic leucine zipper (bZIP) transcription factor that represses or activates transcription in non-osteoblastic cells. NFIL3 play a role in attenuation of PTH target gene transcription in osteoblasts. NFIL3 repression domain interacts specifically with the TBP binding repressor protein Dr1.Glucocorticoid-mediated upregulation of the bZIP transcriptional repressor gene, NFIL3, is dependent on [Ca2+]i levels, and correlates with Glucocorticoid-evoked apoptosis of Glucocorticoid-sensitive CEM-C7-14 cells. NFIL3 is involved in a distinct growth factor-regulated signaling pathway that is responsible for the survival of early B-cell progenitors, and whose alteration by E2A-HLF leads to childhood B lineage leukemia.

Sequência

Synthetic peptide located within the following region: MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEDVLLSEG

forma física

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable