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A7111

Sigma-Aldrich

Acepromazine maleate

≥98% (HPLC)

Sinônimo(s):

Acetopromazine maleate salt, 2-Acetyl-10-(3-dimethylaminopropyl)phenothiazine maleate salt, Acepromazine maleate salt

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About This Item

Fórmula empírica (Notação de Hill):
C19H22N2OS · C4H4O4
Número CAS:
3598-37-6
Peso molecular:
442.53
Número CE:
222-748-9
Número MDL:
MFCD00082473
Código UNSPSC:
12352200
ID de substância PubChem:
329770915
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

condição de armazenamento

protect from light

cor

yellow

solubilidade

H2O: >10 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

OC(=O)\C=C/C(O)=O.CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(C)=O

InChI

1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

chave InChI

FQRHOOHLUYHMGG-BTJKTKAUSA-N

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Aplicação

Acepromazine maleate has been used:
  • as a component of anesthesia cocktail to test its effects on behavioral changes in rats[1]
  • as a component of anesthesia cocktail to study its effects on lung resistance of rats[2]
  • as an anti-psychotic pharmaceutical agent to study its cytotoxic effects on malignant glioma in glioblastoma (GBM) cells[3]

Ações bioquímicas/fisiológicas

Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.
Atypical neuroleptic.

Características e benefícios

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H336

Declarações de precaução

P301 + P310 + P330

Classificações de perigo

Acute Tox. 3 Oral - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000357407
0000357407
0000309181
0000309178
0000230034

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Effect of hypoxia-inducible factor-1/vascular endothelial growth factor signaling pathway on spinal cord injury in rats
Chen H, et al.
Experimental and Therapeutic Medicine, 13(3), 861-866 (2017)
Akari Kamine et al.
The Japanese journal of veterinary research, 60(1), 5-13 (2012-03-31)
The metabolic mechanisms to circannual changes in body mass of bears have yet to be elucidated. We hypothesized that the Japanese black bear (Ursus thibetanus japonicus) has a metabolic mechanism that efficiently converts carbohydrates into body fat by altering insulin
Age-Dependent Progression in Lung Pathophysiology can be Prevented by Restoring Fatty Acid and Ceramide Imbalance in Cystic Fibrosis
Youssef M, et al.
Lung, 13(3), 1-11 (2020)
Frances E Cone et al.
Experimental eye research, 99, 27-35 (2012-05-05)
The purpose of this study was to improve a mouse model of chronic intraocular pressure (IOP) elevation utilizing microbead injection in two strains of mice and to assess the effect of age and anesthesia on measured IOP. We compared our
Mina Youssef et al.
Lung, 198(3), 459-469 (2020-04-20)
Cystic fibrosis (CF) is a progressive disease which causes a continuous decline in lung capacity with age. Our study aimed to investigate the age-dependent deterioration in lung function and the effects of treatment with Fenretinide formulation (LAU-7b) in Cftr knockout
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