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Documentos Principais

A4056

Sigma-Aldrich

Amrinone

Sinônimo(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

Fórmula empírica (Notação de Hill):
C10H9N3O
Número CAS:
Peso molecular:
187.20
Número CE:
Número MDL:
Código UNSPSC:
12352202
ID de substância PubChem:

Ensaio

≥98% (TLC)

Nível de qualidade

Formulário

powder

solubilidade

1 M NaOH: 100 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

chave InChI

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Informações sobre genes

human ... PDE3A(5139)
rat ... Pde3a(50678)

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Ações bioquímicas/fisiológicas

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.

Pictogramas

Skull and crossbones

Palavra indicadora

Danger

Frases de perigo

Declarações de precaução

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Visite a Biblioteca de Documentos

M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
Can Kucuk et al.
The Journal of surgical research, 151(1), 74-79 (2008-05-13)
During some surgical interventions, temporary occlusion of the hepatic blood supply may cause ischemia-reperfusion (IR) injury. Recent studies suggest that type 3 phosphodiesterase inhibitors may have a beneficial effect on liver IR injury. The aim of this study was to
Yoshihiro Ko et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 15(5), 311-317 (2009-11-11)
Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) handling if utilized as a component of terminal
R Karabulut et al.
Urological research, 30(3), 164-168 (2002-07-12)
Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation, shock, cardiac arrest, hemorrhage and renal artery surgery. In this experimental study, we aimed to determine the preventive effects of amrinone on bilateral renal ischemia/reperfusion

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