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Sigma-Aldrich

Pefachrome® uPA

≥95.0% (HPLC)

Sinônimo(s):

N-Benzoyl-β-Ala-Gly-Arg-4-nitroanilide acetate, N-Benzoyl-β-alanyl-glycyl-L-arginine-4-nitroanilide acetate

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About This Item

Fórmula empírica (Notação de Hill):
C24H30N8O6 · C2H4O2
Número CAS:
112283-16-6
Peso molecular:
586.60
Número MDL:
MFCD01940690
Código UNSPSC:
12352200
ID de substância PubChem:
57652706

Ensaio

≥95.0% (HPLC)

forma

powder

solubilidade

water: 5 mg/mL, clear, colorless

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(O)=O.NC(=N)NCCC[C@H](NC(=O)CNC(=O)CCNC(=O)c1ccccc1)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI

1S/C24H30N8O6.C2H4O2/c25-24(26)28-13-4-7-19(23(36)30-17-8-10-18(11-9-17)32(37)38)31-21(34)15-29-20(33)12-14-27-22(35)16-5-2-1-3-6-16;1-2(3)4/h1-3,5-6,8-11,19H,4,7,12-15H2,(H,27,35)(H,29,33)(H,30,36)(H,31,34)(H4,25,26,28);1H3,(H,3,4)/t19-;/m0./s1

chave InChI

LNYCMHUMNWBNSM-FYZYNONXSA-N

Aplicação

Pefachrome® substrates are used for chromogenic assays of various serine proteinases. Pefachrome® uPA is used for the detection of serine proteases such as urokinase-type plasminogen activator (urokinase).

Embalagem

1 piece contains 10 μmol Pefachrome® uPA and 20 mg glycine

Outras notas

Chromogenic substrate test for the detection of urokinase in Shigella

Informações legais

Pefachrome is a registered trademark of Pentapharm AG, Basel

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Rong Pan et al.
The Journal of biological chemistry, 285(30), 22950-22956 (2010-05-21)
Enzymatic catalysis of biochemical reactions is essential to all living systems. The "lock and key" and "induced fit" models were early contributions to our understanding of the mechanisms involved in the reaction between an enzyme and its substrate. However, whether
M F Massenti et al.
Microbiologica, 10(3), 331-333 (1987-07-01)
A simple test for detection of urokinase in Shigella is described. The test is performed by suspending a loopful of bacteria in 100 microliters of a buffered 1mM solution of benzoyl-beta-alanyl glycyl-arginyl-4-nitroanilide acetate (Chromozym U). Enzymatic activity is revealed by
Urokinase-type plasminogen activator (uPA) and matrix metalloproteinase-9 (MMP-9) expression and activity during early embryo development in the cow.
Whiteside EJ, Kan M, Jackson MM, et al.
Anat. Embryol., 204, 477-483 (2001)
Yukari Yamamoto et al.
Journal of dermatological science, 47(2), 119-125 (2007-05-29)
Although pemphigus vulgaris (PV)-IgG has been shown to activate urokinase plasminogen activator (uPA) in cultured keratinocytes, activation of uPA is thought to have no primary role in PV-acantholysis, because PV-IgG is still pathogenic in uPA- and tissue-PA-knockout mice. To determine
D H Rhoney et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 56(20), 2047-2051 (1999-11-30)
The retention of urokinase activity after frozen storage was studied. Urokinase powder was reconstituted aseptically in sterile water for injection or preservative-free 0.9% sodium chloride injection to a final concentration of 5000 IU/mL. Samples were stored in 5-mL plastic syringes

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