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61350

Sigma-Aldrich

TS-Link™ Bimane thiosulfate sodium salt

≥98.0% (HPCE)

Sinônimo(s):

Thiosulfuric acid S-{2-oxo-2-{[(2,5,6-trimethyl-1,7-dioxo-1H,7H-pyrazolo[1,2-a]pyrazol-3-yl)methyl]amino}ethyl}ester monosodium salt

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About This Item

Fórmula empírica (Notação de Hill):
C12H14N3NaO6S2
Número CAS:
852178-18-8
Peso molecular:
383.38
Número MDL:
MFCD12912387
Código UNSPSC:
12352200
ID de substância PubChem:
329759443
NACRES:
NA.32

Ensaio

≥98.0% (HPCE)

fluorescência

λex 386 nm; λem 480 nm in 0.1 M phosphate pH 7.0

adequação

corresponds for coupling to thiols

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na+].CC1=C(C)C(=O)N2N1C(CNC(=O)CSS([O-])(=O)=O)=C(C)C2=O

InChI

1S/C12H15N3O6S2.Na/c1-6-8(3)14-9(7(2)12(18)15(14)11(6)17)4-13-10(16)5-22-23(19,20)21;/h4-5H2,1-3H3,(H,13,16)(H,19,20,21);/q;+1/p-1

chave InChI

CFJHROSVZGHNCG-UHFFFAOYSA-M

Aplicação

TS-Link Bimane thiosulfate sodium salt is used to fluorescence label sulfhydryls found in proteins and other biomolecules such as glutathione. In contrast to the thioether bonds formed by maleimides and iodoacetamides, the disulfide bonds formed by TS-Link reagents are reversible — the TS-Link hapten or fluorophore can easily be removed using a reducing agent such as DTT or TCEP. TS-Link reagents are selective for thiols at neutral pH, whereas maleimides will react with other functional groups. TS-Link Bimane thiosulfate sodium salt may be used in comparison with other sulfhydryl coupling strategies.

Informações legais

TS-Link is a trademark of Life Technologies

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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R C Fahey et al.
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Bioorganic & medicinal chemistry letters, 16(6), 1473-1476 (2006-01-03)
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Pharmaceutical research, 22(7), 1059-1068 (2005-07-20)
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