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17809

Sigma-Aldrich

(−)-Epinephrine (+)-bitartrate salt

tested according to Ph. Eur.

Sinônimo(s):

Adrenalini tartras, L-3,4-Dihydroxy-α-(methylaminomethyl)benzyl alcohol D-hydrogen bitartrate salt, L-Adrenaline (+)-bitartrate salt, L-Adrenaline D-hydrogentartrate, L-Epinephrine D-hydrogentartrate

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About This Item

Fórmula empírica (Notação de Hill):
C9H13NO3 · C4H6O6
Número CAS:
51-42-3
Peso molecular:
333.29
Número CE:
200-097-1
Número MDL:
MFCD00035077
Código UNSPSC:
12352200
ID de substância PubChem:
57647680

Agency

tested according to Ph. Eur.

Nível de qualidade

100

solubilidade

water: soluble 1 gm in 3 ml
alcohol: slightly soluble
chloroform: insoluble
diethyl ether: insoluble

aplicação(ões)

pharmaceutical (small molecule)

cadeia de caracteres SMILES

O[C@H]([C@@H](O)C(O)=O)C(O)=O.CNC[C@H](O)c1ccc(O)c(O)c1

InChI

1S/C9H13NO3.C4H6O6/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;5-1(3(7)8)2(6)4(9)10/h2-4,9-13H,5H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t9-;1-,2-/m01/s1

chave InChI

YLXIPWWIOISBDD-NDAAPVSOSA-N

Informações sobre genes

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , ADRB1(153) , ADRB2(154) , ADRB3(155)

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Aplicação

(-)-Epinephrine (+)-bitartrate salt has been used for studying the active calcium uptake by rainbow trout skin. It has also been used in oxygen-derived oxidant assays for assessing the susceptibility of C. neoformans biofilms to antimicrobial molecules.

Ações bioquímicas/fisiológicas

(-)-Epinephrine (+)-bitartrate salt is an α,β-adrenergic receptor agonist. It inhibits the lipolysis completely and can overcome the antilipolytic impact of insulin in perifused isolated fat cell.
Adrenergic receptor agonist.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 1 Oral

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análise (COA)

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S S Solomon et al.
The Journal of laboratory and clinical medicine, 88(6), 984-994 (1976-12-01)
Development of a perifusion system utilizing isolated fat cells (IFC) has converted the static incubation system into one capable of measuring dynamic changes in adipose tissue metabolism. Using this new system, we have studied the initiation by epinephrine and inhibition
Luis R Martinez et al.
Infection and immunity, 74(11), 6118-6123 (2006-10-24)
The human pathogenic fungus Cryptococcus neoformans can form biofilms on polystyrene plates and medical devices in a process that requires capsular polysaccharide release. Although biofilms are known to be less susceptible to antimicrobial drugs, little is known about their susceptibility
W S Marshall et al.
The Journal of experimental biology, 166, 297-316 (1992-05-01)
The skin overlying the cleithrum bone of freshwater-acclimated rainbow trout contains numerous mitochondria-rich (MR) cells, as detected by DASPEI fluorescence. This tissue was mounted in vitro in an Ussing-style chamber with fresh water on the mucosal surface and saline supplemented
Yangjie Wei et al.
AAPS PharmSciTech, 16(2), 455-465 (2014-11-02)
Several attempts have been made to mask the bitter taste of oral formulations, but none have been made for injectable formulations. This study aims to mask the bitter taste of dental lidocaine HCl (LID) injection using hydroxypropyl-β-cyclodextrin (HP-β-CD) and sodium
Margot Van der Jeught et al.
Cellular reprogramming, 17(3), 170-180 (2015-06-09)
In mice, inhibition of both the fibroblast growth factor (FGF) mitogen-activated protein kinase kinase/extracellular-signal regulated kinase (MEK/Erk) and the Wnt signaling inhibitor glycogen synthase-3β (GSK3β) enables the derivation of mouse embryonic stem cells (mESCs) from nonpermissive strains in the presence
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