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Y0001242

Folic acid impurity A

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

N-(4-Aminobenzoyl)-L-glutamic acid

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About This Item

Fórmula empírica (Notação de Hill):
C12H14N2O5
Número CAS:
Peso molecular:
266.25
Beilstein:
2816320
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

pharmaceutical primary standard

família API

folic acid

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Nc1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

InChI

1S/C12H14N2O5/c13-8-3-1-7(2-4-8)11(17)14-9(12(18)19)5-6-10(15)16/h1-4,9H,5-6,13H2,(H,14,17)(H,15,16)(H,18,19)/t9-/m0/s1

chave InChI

GADGMZDHLQLZRI-VIFPVBQESA-N

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Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Folic acid impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

Nº do produto
Descrição
Preços

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Pteroic acid ≥93%

Sigma-Aldrich

P1781

Pteroic acid

Biotina European Pharmacopoeia (EP) Reference Standard

Y0001978

Biotina

L-cistina European Pharmacopoeia (EP) Reference Standard

C3300000

L-cistina

Sacarose European Pharmacopoeia (EP) Reference Standard

S1600000

Sacarose

Gale G Bozzo et al.
Phytochemistry, 69(1), 29-37 (2007-08-19)
Folates break down in vivo to give pterin and p-aminobenzoylglutamate (pABAGlu) fragments, the latter usually having a polyglutamyl tail. Pilot studies have shown that plants can hydrolyze pABAGlu and its polyglutamates to p-aminobenzoate, a folate biosynthesis precursor. The enzymatic basis
M A Caudill et al.
The Journal of nutrition, 128(2), 204-208 (1998-03-07)
Measurement of the urinary folate catabolites, para-aminobenzoylglutamate (pABG) and the more predominant acetylated form, acetamidobenzoylglutamate (apABG), has been used to assess folate requirements in both pregnant and nonpregnant women. Folate catabolite excretion has been reported to be significantly higher in
Eric L Carter et al.
Journal of bacteriology, 189(9), 3329-3334 (2007-02-20)
Escherichia coli AbgT was first identified as a structural protein enabling the growth of p-aminobenzoate auxotrophs on exogenous p-aminobenzoyl-glutamate (M. J. Hussein, J. M. Green, and B. P. Nichols, J. Bacteriol. 180:6260-6268, 1998). The abg region includes abgA, abgB, abgT
J F Gregory et al.
The Journal of nutrition, 128(11), 1896-1906 (1998-11-10)
In a 10-wk study of folate metabolism in nonpregnant women (21-27 y, n -6 per group), subjects were fed a diet containing approximately 68 nmol/d (30 microg/d) folate from food. The remainder of the ingested folate was provided as folic
Rita Hannisdal et al.
Clinical chemistry, 54(4), 665-672 (2008-02-19)
The development of accurate and precise folate assays has been difficult, mainly because of folate instability. Large interassay and interlaboratory differences have been reported. We therefore developed a serum folate assay that measures folate and putative degradation products as p-aminobenzoylglutamate

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