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PHR1110

Supelco

L-Alanine

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

(S)-2-Aminopropionic acid, L-α-Aminopropionic acid

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About This Item

Fórmula empírica (Notação de Hill):
C3H7NO2
Número CAS:
Peso molecular:
89.09
Beilstein:
1720248
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to Ph. Eur. A0325000
traceable to USP 1012509

família API

alanine

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

C[C@H](N)C(O)=O

InChI

1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

chave InChI

QNAYBMKLOCPYGJ-REOHCLBHSA-N

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Descrição geral

L-Alanine, a non-essential amino acid, is produced enzymatically from L-aspartate using aspartate β-decarboxylase. It is the smallest among all the amino acids.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicação

L-Alanine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using high-performance liquid chromatography (HPLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAA7160 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

produto relacionado

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Sigma-Aldrich

A7469

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Sigma-Aldrich

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Sigma-Aldrich

W381829

L-Alanine

Control of impurities in l-aspartic acid and l-alanine by high-performance liquid chromatography coupled with a corona charged aerosol detector
Holzgrabe U, et al.
Journal of Chromatography A, 1217(3), 294-301 (2010)
J M Rhoads et al.
Journal of pediatric gastroenterology and nutrition, 9(2), 225-231 (1989-08-01)
We studied sodium-dependent uptake of L-alanine into small intestinal brush border membrane vesicles (BBMV) isolated from piglets 40 h after infection with transmissible gastroenteritis (TGE) virus. Vesicles from TGE-infected pigs and uninfected litter-mate controls showed comparable degrees of enrichment and
Lillian L Siu et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(19), 2477-2484 (2013-05-22)
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Rachelle S Doody et al.
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Alzheimer's disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase on amyloid precursor protein. Semagacestat is a small-molecule γ-secretase inhibitor that was developed as a potential treatment
Mom Das et al.
Nucleic acids research, 42(6), 3943-3953 (2013-12-29)
Errors in protein synthesis due to mispairing of amino acids with tRNAs jeopardize cell viability. Several checkpoints to prevent formation of Ala- and Cys-tRNA(Pro) have been described, including the Ala-specific editing domain (INS) of most bacterial prolyl-tRNA synthetases (ProRSs) and

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