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Documentos Principais

I0775010

Isosorbide mononitrate

European Pharmacopoeia (EP) Reference Standard

Sinônimo(s):

1,4:3,6-Dianhydro-D-glucitol 5-nitrate

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About This Item

Fórmula empírica (Notação de Hill):
C6H9NO6
Número CAS:
16051-77-7
Peso molecular:
191.14
Número CE:
240-197-2
Código UNSPSC:
41116107
NACRES:
NA.24
Preço e disponibilidade não estão disponíveis no momento.

grau

pharmaceutical primary standard

família API

isosorbide

fabricante/nome comercial

EDQM

aplicação(ões)

pharmaceutical (small molecule)

Formato

neat

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[N+](=O)([O-])O[C@H]1[C@H]2OC[C@@H]([C@H]2OC1)O

InChI

1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4+,5+,6+/m0/s1

chave InChI

YWXYYJSYQOXTPL-SLPGGIOYSA-N

Descrição geral

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicação

Isosorbide mononitrate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Embalagem

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Outras notas

Sales restrictions may apply.

produto relacionado

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Descrição
Preços

Pictogramas

Flame
GHS02

Palavra indicadora

Danger

Frases de perigo

H228

Declarações de precaução

P210 - P240 - P241 - P280 - P370 + P378

Classificações de perigo

Flam. Sol. 1

Código de classe de armazenamento

4.1A - Other explosive hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number

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Athanasios Mousiolis et al.
Contraception, 88(1), 41-44 (2013-01-08)
Isosorbide mononitrate (IMN) administration is thought to enhance in the cervical ripening process. We sought to identify the clinical usefulness and safety of IMN administration for shortening the time to termination of the second trimester pregnancy procedures when used in
Francesca Fabrizi et al.
Journal of enzyme inhibition and medicinal chemistry, 27(1), 138-147 (2011-08-06)
The clinically used sulfonamide carbonic anhydrase (CA, EC 4.2.1.1) inhibitor dorzolamide (DRZ), a new sulfonamide CA inhibitor also incorporating NO-donating moieties, NCX250, and isosorbide mononitrate (ISMN) (an NO-donating compound with no CA inhibitory properties) were investigated for their intraocular pressure
U W Abshagen
The American journal of cardiology, 70(17), 61G-66G (1992-11-27)
Pharmacokinetic studies show that isosorbide mononitrate is rapidly absorbed after oral administration, reaches peak concentrations within an hour, undergoes no significant first-pass metabolism, and is virtually 100% bioavailable. The half-life is approximately 5 hours, the volume of distribution is 0.62
Sayeed Hasan et al.
Journal of pharmaceutical sciences, 106(12), 3556-3563 (2017-08-27)
Extracellular polymeric substances in bacterial biofilms reduce the penetration of antimicrobials and give rise to extreme recalcitrance and treatment challenges for many persistent biofilms and associated infections. Nitric oxide (NO) is a promising alternative to conventional antimicrobials but is challenging
U Thadani et al.
The American journal of cardiology, 70(17), 67G-71G (1992-11-27)
The rapid development of tolerance has limited the applicability of oral and transdermal nitrates in the long-term management of patients with chronic stable angina pectoris. Recent well-controlled trials have demonstrated that asymmetrical, or eccentric, dosing of oral isosorbide mononitrate, in
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