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94339

Sigma-Aldrich

Ácido uridino 5′-difosfoglicurônico

≥99.0% (HPLC)

Sinônimo(s):

UDP-GlcA, UDPGA, Ácido uridino difosfato glicurônico, Ácido uridino[5′]difosfo[1]-α-D-glicopiranosurônico

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About This Item

Fórmula empírica (Notação de Hill):
C15H19N2Na3O18P2
Número CAS:
63700-19-6
Peso molecular:
646.23
Número MDL:
MFCD03452710
Código UNSPSC:
41106305
ID de substância PubChem:
329770328

fonte biológica

animal

Ensaio

≥99.0% (HPLC)

Impurezas

≤10% water
≤4% solvent (ethanol)

solubilidade

H2O: 10 mg/mL, clear, colorless

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[Na+].[Na+].[Na+].O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C([O-])=O)OP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O

InChI

1S/C15H22N2O18P2.3Na/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25;;;/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26);;;/q;3*+1/p-3/t4-,6-,7+,8+,9-,10-,11+,12-,14-;;;/m1.../s1

chave InChI

XXXUNWUNTOMVIG-QWGSIYABSA-K

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Nº do produto
Descrição
Preços

Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Xenobiotica; the fate of foreign compounds in biological systems, 44(8), 716-721 (2014-03-13)
1. The aurantio-obtusin's glucuronide was detected when aurantio-obtusin was incubated with human liver microsomes (HLMs). Recombinant UGT isoforms screening experiment showed that UGT1A8 was the major isoform contributed to the glucuronidation. 2. The metabolic profiles for aurantio-obtusin in liver microsomes
Jian Yu et al.
Phytotherapy research : PTR, 28(10), 1577-1580 (2014-05-21)
The present study aims to investigate the influence of irinotecan's toxicity by the biotransformation of glucoaurantio-obtusin to aurantio-obtusin. Intraperitoneal administration (i.p.) of 100 mg/kg aurantio-obtusin significantly increased the toxicity of irinotecan, but the i.p. administration of 100 mg/kg glucoaurantio-obtusin showed
Evamaria Falck et al.
Journal of pharmaceutical and biomedical analysis, 94, 36-44 (2014-02-19)
Structural modification of the GluN2B selective NMDA receptor antagonist ifenprodil led to the 3-benzazepine WMS-1410 with similar GluN2B affinity but higher receptor selectivity. Herein the in vitro and in vivo biotransformation of WMS-1410 is reported. Incubation of WMS-1410 with rat
Alexandra Maier-Salamon et al.
International journal of oncology, 45(2), 877-886 (2014-06-04)
The metabolism of 9-aminocamptothecin (9-AC) was investigated in human and rat liver microsomes. In both species 9-AC was almost exclusively biotransformed to dihydroxy-9-AC (M1) and monohydroxy-9-AC (M2). The enzymatic efficiencies of the formation of M1 and M2 (V(max)/K(m)) were 1.7-
Bo Tan et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(9), 775-784 (2014-03-19)
Leonurine is a potent component of herbal medicine Herba leonuri. The detail information on leonurine metabolism in human has not been revealed so far. Two primary metabolites, leonurine O-glucuronide and demethylated leonurine, were observed and identified in pooled human liver
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