MAB4150
Anti-MRP2 Antibody, CT, clone M2 III-6
culture supernatant, clone M2 III-6, Chemicon®
Sinônimo(s):
cMOAT
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
fonte biológica
mouse
Nível de qualidade
forma do anticorpo
culture supernatant
tipo de produto de anticorpo
primary antibodies
clone
M2 III-6, monoclonal
reatividade de espécies
human
fabricante/nome comercial
Chemicon®
técnica(s)
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
Isotipo
IgG2a
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
Informações sobre genes
human ... ABCC2(1244)
Especificidade
This antibody reacts with an internal epitope of MRP2, a 190-200 kDa transmembrane protein previously known as the canalicular multi-organic anion transporter (cMOAT). MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 over expression has been observed in a subset of cisplatin resistant cell lines. This antibody does not cross-react with the human MDR1, MRP1, MRP3 or MRP5 gene products.
Imunogênio
Bacterial fusion protein of MRP2 containing the 202-aa C-terminal end
Epitope: C-terminus
Aplicação
Detect MRP2 using this Anti-MRP2 Antibody, C-terminus, clone M2 III-6 validated for use in WB, IC, IH, IH(P).
Research Category
Metabolism
Metabolism
Research Sub Category
Toxicology & Drug Resistance
Toxicology & Drug Resistance
Western blotting: 1:20 - 1:50 with anti-mouse HRP
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections; 1:20 on formaldehyde-fixed paraffin-embedded tissues (pretreat with 0.01M citrate, pH 6.0, in dH2O at 100ºC for 5 minutes, repeated 3 times)
Optimal working dilutions must be determined by end user.
Immunocytochemistry: 1:20 - 1:50 on acetone fixed cytospin preparations
Immunohistochemistry: 1:20 on acetone fixed frozen tissue sections; 1:20 on formaldehyde-fixed paraffin-embedded tissues (pretreat with 0.01M citrate, pH 6.0, in dH2O at 100ºC for 5 minutes, repeated 3 times)
Optimal working dilutions must be determined by end user.
forma física
Liquid containing 0.7% BSA and 0.1% sodium azide.
Armazenamento e estabilidade
Maintain refrigerated at 2-8°C for up to 6 months. For long-term storage store at -20°C.
Outras notas
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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C C Paulusma et al.
Science (New York, N.Y.), 271(5252), 1126-1128 (1996-02-23)
The human Dubin-Johnson syndrome and its animal model, the TR(-) rat, are characterized by a chronic conjugated hyperbilirubinemia. TR(-) rats are defective in the canalicular multispecific organic anion transporter (cMOAT), which mediates hepatobiliary excretion of numerous organic anions. The complementary
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines.
Igarashi, T; Izumi, H; Uchiumi, T; Nishio, K; Arao, T; Tanabe, M; Uramoto, H; Sugio et al.
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Cifford W Mason et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(6), 1000-1007 (2011-03-25)
Fetal drug exposure is determined by the type and concentration of placental transporters, and their regulation is central to the development of new treatments and delivery strategies for pregnant women and their fetuses. We tested the expression of several clinically
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