ABN648

Anti-TRESK Antibody

from rabbit, purified by affinity chromatography

• Sinônimo(s): Potassium channel subfamily K member 18, TWIK-related individual potassium channel, TWIK-related spinal cord potassium channel
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• purificado por: affinity chromatography
• reatividade de espécies: rat
• técnica(s): immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• nº de adesão UniProt: Q7Z418
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: rat ... Kcnk18(445371)

Descrição

Descrição geral

Potassium channel subfamily K member 18, also known as TWIK-related individual potassium channel or TWIK-related spinal cord potassium channel, and encoded by the gene name KCNK18 or TRESK or TRIK, is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic Tlymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction. Mutations in TRESK have been assoicated with migraine with or without aura 13.

Imunogênio

KLH-conjugated synthetic peptide corresponding to the center region of human TRESK.

Aplicação

Anti-TRESK Antibody is an antibody against TRESK for use in western blotting, IHC & immunofluorescence.

Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected TRESK in rat brain tissue.

Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TRESK in rat brain cells.

Qualidade

Evaluated by Western Blotting in Rat brain tissue lysate.

Western Blotting Analysis: 2 μg/mL of this antibody detected TRESK in Rat brain tissue lysate.

Descrição-alvo

~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable