AB15138

Anti-Nogo Receptor Antibody

from rabbit

• Sinônimo(s): Reticulon-4 receptor, Nogo receptor, NgR, Nogo-66 receptor, Nogor, Rtn4r
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• forma do anticorpo: purified antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• reatividade de espécies: mouse, human, rat
• técnica(s): immunohistochemistry: suitable; western blot: suitable
• nº de adesão NCBI: NM_022982
• nº de adesão UniProt: Q99PI8
• Condições de expedição: wet ice
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: mouse ... Rtn4R(65079)

Descrição

Descrição geral

Axons are essential for neuronal communication but they do not regenerate after injury to the adult mammalian brain or spinal cord. Failed regeneration is due in part to the production of a potent axonal growth inhibitor, Nogo, by myelinating cells. The finding of a high affinity axonal receptor for the extracellular domain of Nogo provides the first insight into the basis of Nogo action. Disrupting the interaction of Nogo with the Nogo-66 receptor may facilitate axonal regeneration in vivo. The protein is dubbed the Nogo receptor because it binds with several other proteins that block neural growth. It is found to be ubiquitous in the brain and spinal cord.

Especificidade

Cat. # AB15138 recognizes the mature form of Nogo Receptor.

May react with human and primate based on sequence homology. Reactivity with other species has not been determined.

Imunogênio

Epitope: Mature Form

Recombinant protein.

Aplicação

Anti-Nogo Receptor Antibody detects level of Nogo Receptor & has been published & validated for use in WB, IH.

Non-Lot Specific Tested Application 1:
Immunohistochemistry: Working dilutions of 1:50-1:500 in rat brain and spinal cord (paraffin embedded)

Research Category
Neuroscience

Research Sub Category
Growth Cones & Axon Guidance

Qualidade

Routinely tested on mouse cerebellum lysate.
Lot Specific Tested Application 1: Western Blot

Descrição-alvo

~50.9 kDa

forma física

Format: Purified

Protein A purified

Purified in PBS with 0.1% NaN3

Armazenamento e estabilidade

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Nota de análise

Control
Mouse cerebellum lysate

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable