8.52199

Fmoc-Asp(OtBu)-Thr(psiMe,Mepro)-OH

Novabiochem^®

• Sinônimo(s): Fmoc-Asp(OtBu)-Thr(psiMe,Mepro)-OH
• Fórmula empírica (Notação de Hill): C₃₀H₃₆N₂O₈
• Número CAS: 920519-32-0
• Peso molecular: 552.62
• Número MDL: MFCD18427721
• Código UNSPSC: 12352209
• NACRES: NA.22

Propriedades

• Nível de qualidade: 200
• linha de produto: Novabiochem^®
• Ensaio: ≥95% (TLC); ≥97.0% (HPLC)
• Formulário: powder
• adequação da reação: reaction type: Fmoc solid-phase peptide synthesis
• fabricante/nome comercial: Novabiochem^®
• aplicação(ões): peptide synthesis
• grupo funcional: hydroxyl
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: N4([C@@H]([C@H](OC4(C)C)C)C(=O)O)C(=O)[C@@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)CC(=O)OC(C)(C)C
• InChI: 1S/C30H36N2O8/c1-17-25(27(35)36)32(30(5,6)39-17)26(34)23(15-24(33)40-29(2,3)4)31-28(37)38-16-22-20-13-9-7-11-18(20)19-12-8-10-14-21(19)22/h7-14,17,22-23,25H,15-16H2,1-6H3,(H,31,37)(H,35,36)/t17-,23+,25+/m1/s1
• chave InChI: NKQJRYSIZOXCTJ-LAMXGVLKSA-N

Descrição

Descrição geral

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Asp-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Ligação

Replaces: 05-20-1126

Nota de análise

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -23.5 - -18.5 °
Purity (TLC(011A)): ≥ 95 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Impurities (single): ≤ 1.00 % (a/a)
Ethyl acetate (HS-GC): ≤ 2.0 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Informações legais

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable