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Documentos Principais

8.00907

Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

for peptide synthesis

Sinônimo(s):

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride

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500 MG
R$ 299,00

R$ 299,00


Previsão de entrega em01 de maio de 2025


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500 MG
R$ 299,00

About This Item

Fórmula empírica (Notação de Hill):
C8H17N3 · xHCl
Número CAS:
Peso molecular:
155.24 (free base basis)
Número MDL:
Código UNSPSC:
12352107
Número do índice EC:
247-361-2
NACRES:
NA.22

R$ 299,00


Previsão de entrega em01 de maio de 2025


Solicite uma grande encomenda

Nome do produto

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, for synthesis

Nível de qualidade

Formulário

solid

adequação da reação

reaction type: Coupling Reactions

pf

110-115 °C

aplicação(ões)

peptide synthesis

temperatura de armazenamento

−20°C (−15°C to −25°C)

cadeia de caracteres SMILES

Cl.N(CCCN(CC)C#N)(C)C

InChI

1S/C8H17N3.ClH/c1-4-11(8-9)7-5-6-10(2)3;/h4-7H2,1-3H3;1H

chave InChI

FDXPUDRRFDHONO-UHFFFAOYSA-N

Descrição geral

N-(3-Dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride, also known as EDAC HCl or WSC, is a water-soluble condensing reagent. EDAC HCl is generally used to couple carboxylic acids with amines to form amides. The by-product urea is water-soluble and can be removed from immiscible reaction milieux by extraction with water. It is principally utilized in solution-phase peptide synthesis and as a zero-length crosslinker for protein modification.

Aplicação

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC hydrochloride) can be used as:
  • A water-soluble carbodiimide to facilitate peptide coupling reactions in alcohols.[1]
  • A coupling agent along with HOBt to synthesize poly(glutamic acid) (PGA) polypeptides for the creation of non-fouling polypeptides that could be useful in a variety of biomedical applications.[2]
  • A coupling reagent for the efficient synthesis of teriflunomide at the industrial scale.[3]

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2 Oral

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Certificados de análise (COA)

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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. The packaging instructions recommend storing the item under an inert gas, but the safety data sheet does not specify this requirement. Would it suffice to store it in a refrigerator at -20°C instead?

    1 answer
    1. The recommended long term storage of this item is -15°C to -25°C. Clearing the headspace of the vial with argon before resealing is recommended. The stability of the product when stored otherwise cannot be guaranteed.

      Helpful?

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