585970

(±)-Thalidomide

Selective inhibitor of TNF-α biosynthesis.

• Sinônimo(s): (±)-Thalidomide, (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Fórmula empírica (Notação de Hill): C₁₃H₁₀N₂O₄
• Número CAS: 50-35-1
• Peso molecular: 258.23
• Número MDL: MFCD00153873
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze
• cor: white
• solubilidade: DMSO: 25 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 10-30°C
• InChI: 1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17)
• chave InChI: UEJJHQNACJXSKW-UHFFFAOYSA-N

Descrição

Descrição geral

Selective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Selective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
TNF-α biosynthesis

Product does not compete with ATP.

Reversible: no

Advertência

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

Reconstituição

Following reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Gershon, D. 1995. Nat. Med.1, 1230.
Thompson, C. 1995. Lancet 346, 1289.
Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H312,H360D
• Declarações de precaução: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Classificações de perigo: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Repr. 1A
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3