555556

Rho Kinase Inhibitor VII

The Rho Kinase Inhibitor VII controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinônimo(s): Rho Kinase Inhibitor VII, ROCK Inhibitor VII, Rho Kinase Inhibitor VII
• Fórmula empírica (Notação de Hill): C₂₁H₂₄N₈
• Peso molecular: 388.47
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; desiccated (hygroscopic); protect from light
• cor: light beige
• solubilidade: DMSO: 1 mg/mL; water: 1 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A cell-permeable triaminotriazine ROCK inhibitor (IC₅₀ = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC₅₀ >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC₅₀ = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.

A cell-permeable triaminotriazine ROCK inhibitor (IC₅₀ = 6 nM in a cell-free ROCK1 kinase assay) that affects 24 other commonly studied non-ROCK kinases only at much higher concentrations (IC₅₀ >2 µM) and effectively blocks MCP-1-induced THP-1 cell migration (IC₅₀ = 30 nM) in vitro. Subcutaneous injection (3-10 mg/kg) of ROCK Inhibitor VII and oral dosing (30 mg/kg) of Y-27632 (Cat. Nos. 688000 & 688001) are both reported to significantly reduce arterial blood pressure in a spontaneous hypertensive rat model in vivo.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Ho, K.K., et al. 2009. Bioorg. Med. Chem. Lett.19, 6027.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable