5.08507

Isradipine

• Sinônimo(s): Isradipine, L-type voltage-gated Ca2+ channel blocker, Isradipine, PN 200-110
• Fórmula empírica (Notação de Hill): C₁₉H₂₁N₃O₅
• Número CAS: 75695-93-1
• Peso molecular: 371.39
• Número MDL: MFCD00153820
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 100 mM; ethanol: 50 mM
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
• chave InChI: HMJIYCCIJYRONP-UHFFFAOYSA-N

Descrição

Descrição geral

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

A water soluble voltage gated calcium channel gating inhibitor of the dihydropyridine class. In human ion channels, Isradipine has gating inhibition on Cav1.4 channels (1x10E-6 M) and Cav1.3 (3x10E-8) and in mouse ion channels a pIC₅₀ of 6.7. Often prescribed for hypertension (trade names DynaCirc, Prescal), recent animal models suggest a use in Parkinson′s Disease.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Ações bioquímicas/fisiológicas

Primary Target
CaV

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Chan, C. S. et al. 2007. Nature.447, 1081.
Baumann, L. et al. 2004. Invest. Ophthalmol. Vis. Sci.45, 708.
Koschak, A. et al. 2003. J. Neurosci.23, 6041.
Koschak, A. et al. 2001. J. Biol Chem276, 22100.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable