5.06415

SB-269970 Hydrochloride

• Sinônimo(s): SB-269970 Hydrochloride, 5-HT7 Serotonin receptor antagonist, SB-269970, SB 26,970, SB 26,970
• Fórmula empírica (Notação de Hill): C₁₈H₂₈N₂O₃S · xHCl
• Número CAS: 261901-57-9
• Peso molecular: 352.49 (free base basis)
• Número MDL: MFCD03788020
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Nível de qualidade: 100
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: DMSO: soluble
• temperatura de armazenamento: 2-8°C
• InChI: 1S/C18H28N2O3S.ClH/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18;/h2,5-6,14-16,21H,3-4,7-13H2,1H3;1H/t16-;/m1./s1
• chave InChI: XQCJOYZLWFNDIO-PKLMIRHRSA-N

Descrição

Descrição geral

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

Ações bioquímicas/fisiológicas

Primary Target
5-HT₇

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Tokarski, K. et al. 2012. Pharmacol. Rep.64, 256.
Thomas. D. R. et al. 2000. Br. J. Pharmacol.130, 409.
Lovell, P. J. et al. 2000. J. Med. Chem.43, 342.

Forbes, I. T. et al. 1998. J. Med. Chem.41, 655.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable