5.04479

JNJ 16259685 - CAS 409345-29-5 - Calbiochem

• Sinônimo(s): JNJ 16259685 - CAS 409345-29-5 - Calbiochem, (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone
• Fórmula empírica (Notação de Hill): C₂₀H₂₃NO₃
• Número CAS: 409345-29-5
• Peso molecular: 325.40
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥98% (TLC)
• Nível de qualidade: 100
• Formulário: solid
• potência: 0.55 nM IC₅₀; 0.34 nM K_i
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white to off-white
• solubilidade: DMSO: 25 mM
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

An extremely potent, non-competitive antagonist for mGlu receptor subtype 1 (K_i = 0.34 nM; IC₅₀ = 0.55 nM). 400-fold more selective for mGlu₁ than for mGlu₅ and no interaction with mGlu₂, mGlu₃, mGlu₄, mGlu₆, AMPA or NMDA receptors (IC₅₀ >10 µM). Centrally active following systemic administration. Widely used for studying substance abuse, learning and memory, and neural plasticity.

Ações bioquímicas/fisiológicas

Primary Target
mGlu₁

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Lavreysen, H., et al. 2004. Neuropharmacology.47, 961.

Steckler, T., et al. 2005. Psychopharmacology.179, 198.

Steckler, T., et al. 2005. Behav. Brain. Res.164, 52.

Mabire, D., et al. 2005. J. Med. Chem.48, 2134.
Fukunaga, I., et al. 2007. Br. J. Pharmacol.151, 870.

Knopfel, T., et al. 2007. Br. J. Pharmacol.151, 723.

Achat-Mendes, C., et al. 2012. J. Pharmacol. Exp. Ther.343, 214.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany