481414

NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem

The NF-κB Activation Inhibitor VI, BOT-64, also referenced under CAS 113760-29-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinônimo(s): NF-κB Activation Inhibitor VI, BOT-64 - CAS 113760-29-5 - Calbiochem, 6,6-Dimethyl-2-(phenylimino)-6,7-dihydro-5H-benzo[1,3]oxathiol-4-one
• Fórmula empírica (Notação de Hill): C₁₅H₁₅NO₂S
• Número CAS: 113760-29-5
• Peso molecular: 273.35
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥95% (HPLC)
• Formulário: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: off-white
• solubilidade: ethanol: 10 mg/mL; DMSO: 50 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

A cell-permeable benzoxathiole compound that acts as an IKK-2 inhibitor, presumably by targeting the Ser¹⁷⁷ and/or Ser¹⁸¹ residues in the kinase′s activation loop domain. Shown to inhibit LPS-induced NF-κB activation and nitrite production (IC₅₀ = 1.0 & 0.7 µM, respectively) in RAW 264.7 cells in vitro and effectively prevent LPS-induced septic death in mice (70% survival rate with 30 mg/kg BOT-64, i.p.) in vivo.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Outras notas

Kim, B.H., et al. 2008. Mol. Pharmacol.73, 1309.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable