219457

Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem

• Sinônimo(s): Cdk Inhibitor, p35 - CAS 471270-60-7 - Calbiochem, 2-(3-Hydroxypropylamino)-6-( o-hydroxybenzylamino)-9-isopropylpurine
• Fórmula empírica (Notação de Hill): C₁₈H₂₄N₆O₂
• Número CAS: 471270-60-7
• Peso molecular: 356.42
• Código UNSPSC: 12352200

Propriedades

• Ensaio: ≥95% (HPLC)
• Nível de qualidade: 100
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: yellow
• solubilidade: DMSO: 10 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: −20°C

Descrição

Descrição geral

This product has been discontinued.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects. The correlation between inhibition of Cdk1/Cdk2 and inhibition of cell proliferation suggests that the anti-proliferative effects are due, in part, to Cdk inhibition.

An analog of Olomoucine (Cat. No. 495620) that acts as a potent inhibitor of Cdk1 (IC₅₀ = 100 nM) and Cdk2 (IC₅₀ = 80 nM). Also displays anti-proliferative and pro-apoptotic effects.

Ações bioquímicas/fisiológicas

Cell permeable: no

Primary Target
CDK1, CDK2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM, 80 nM, against Cdk1 and Cdk2, respectively

Embalagem

Packaged under inert gas

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Vermeulen, K., et al. 2002. Leukemia16, 299.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 10-13 - German Storage Class 10 to 13