14-781-M

PI3 Kinase (p110α(E545K)/p85α), Murine

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propriedades

• recombinante: expressed in baculovirus infected Sf21 cells
• Nível de qualidade: 100; 300
• descrição: protein target PI3Kα/p85α
• purificado por: (Ni²⁺/NTA-agarose)
• técnica(s): activity assay: suitable
• nº de adesão UniProt: P42336
• Informações sobre genes: mouse ... PIK3CA(18706)

Descrição

Descrição geral

FUNCTION: SwissProt: P42336 # Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2.
SIZE: 1068 amino acids; 124284 Da
SUBUNIT: Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunit. Binds to IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity).
DISEASE: SwissProt: P42336 # Defects in PIK3CA are associated with colorectal cancer (CRC) [MIM:114500]. & Defects in PIK3CA are associated with breast cancer [MIM:114480]. & Defects in PIK3CA are associated with epithelial ovarian cancer (EOC) [MIM:604370].
SIMILARITY: SwissProt: P42336 ## Belongs to the PI3/PI4-kinase family. & Contains 1 C2 domain. & Contains 1 PI3K/PI4K domain.

Embalagem

Also available in 250 μg size --call for pricing and availability and reference catalog number 14-781M when ordering the 250 μg size.

Also available in 10 μg size (cat#14-781) and in bulk (cat# 14-781-K).

propriedades físicas

p110α (Ε545Κ) MW = 129kDa,
p85α MW = 83.6kDa.

Armazenamento e estabilidade

Store at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap. Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.

Nota de análise

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classificações de perigo: Skin Sens. 1
• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable