14-347-M

CHK2 Protein, active, 10 µg

Active, recombinant human CHK2, residues 5-543, containing N-terminal GST & C-terminal His-6 tags, for use in Kinase Assays.

• Código UNSPSC: 12352202
• eCl@ss: 32160405
• NACRES: NA.32

Propriedades

• fonte biológica: human
• Nível de qualidade: 100
• recombinante: expressed in E. coli
• linha de produto: Upstate^®
• atividade específica: (For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)
• peso molecular: M_w 89.6 kDa
• purificado por: (glutathione-agarose and Ni²⁺/NTA-agarose)
• reatividade de espécies: human
• fabricante/nome comercial: Upstate^®
• técnica(s): activity assay: suitable (kinase)
• nº de adesão: (FUNCTION: SwissProt: O96017 # Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on ′Ser-216′, preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at ′Thr-18′ and ′Ser-20′. ); NM_001005735.1
• nº de adesão NCBI: NM_001005735.1; NM_007194.3; NM_145862.2
• nº de adesão UniProt: O96017
• Informações sobre genes: human ... CHEK2(11200)

Descrição

Descrição geral

Recombinant human CHK2, residues 5-543, containing N-terminal GST and Cterminal His6 tags

Ações bioquímicas/fisiológicas

Protein Target: CHK2

Target Sub-Family: CAMK

Embalagem

Also available in 10 μg size and in bulk

Also available in 250 µg size --call for pricing and availability and reference catalog number 14-347M when ordering the 250 µg size.

Qualidade

routinely evaluated by phosphorylation of the CHKtide substrate peptide

Descrição-alvo

CHK2

forma física

glutathione-agarose and Ni²⁺/NTA-agarose

Armazenamento e estabilidade

1 year at -70°C

Outras notas

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H317
• Declarações de precaução: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classificações de perigo: Skin Sens. 1
• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°C): Not applicable