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COA/CoQ

07-1458

Anti-ROCK-1/2 Antibody

Name: Anti-ROCK-1/2 Antibody
Brand: MM

from rabbit, purified by affinity chromatography

Sinônimo(s):

Renal carcinoma antigen NY-REN-35, Rho kinase, Rho-associated, coiled-coil containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase 1, p160 ROCK-1

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About This Item

Código UNSPSC:

12352203

eCl@ss:

32160702

NACRES:

NA.41

Preço e disponibilidade não estão disponíveis no momento.

fonte biológica

rabbit

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

purificado por

affinity chromatography

reatividade de espécies

human, mouse

técnica(s)

western blot: suitable

nº de adesão NCBI

NP_005397.1

nº de adesão UniProt

Q13464

Condições de expedição

wet ice

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... ROCK1(6093)
mouse ... Rock1(19877)

Descrição geral

Rho-Associated Kinase (Rho-Kinase or ROK) has been classified into two isoforms: ROKα/ROCK-II and ROKβ/ROCK-I. These large cellular proteins (150-160 kDa), have been reported to be involved in the formation of stress fibers, focal adhesions and cardiac hypertonic responses. Current research suggests that ROK of smooth muscle may be involved in the contractile process via phosphorylation of MYPT1 and Myosin. The serine-threonine kinase ROCK-1 is a down-stream effector of Rho, and is involved in signal transduction pathways that regulate cell morphology, motility, and tumor progression through the reorganization of the actin cytoskeleton.

Especificidade

This antibody recognizes ROCK-1 and ROCK-2.

Imunogênio

Synthetic peptide corresponding to human ROCK-1, 90.5% homology with ROCK-2

Aplicação

This Anti-ROCK-1/2 Antibody is validated for use in WB for the detection of ROCK-1/2.

Qualidade

Evaluated by Western Blot in A431 cell lysate.
Western Blot Analysis: 1:500 dilution of this antibody detected ROCK-1/2 on 10 µg of A431 cell lysate.

Descrição-alvo

158 kDa

Ligação

Replaces: 04-1121

Outras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Nonphosphorylatable Src Ser75 Mutation Increases Ethanol Preference and Consumption in Mice.

Goro Kato

eNeuro, 6(2) (2019-04-10)

Src is highly expressed in CNS neurons and contributes not only to developmental proliferation and differentiation but also to high-order brain functions, such as those contributing to alcohol consumption. Src knock-out mice exhibit no CNS abnormalities, presumably due to compensation

A novel small-molecule MRCK inhibitor blocks cancer cell invasion.

Mathieu Unbekandt et al.

Cell communication and signaling : CCS, 12, 54-54 (2014-10-08)

The myotonic dystrophy kinase-related CDC42-binding kinases MRCKα and MRCKβ regulate actin-myosin contractility and have been implicated in cancer metastasis. Along with the related ROCK1 and ROCK2 kinases, the MRCK proteins initiate signalling events that lead to contractile force generation which

ALW-II-41-27, an EphA2 inhibitor, inhibits proliferation, migration and invasion of cervical cancer cells via inhibition of the RhoA/ROCK pathway.

Xiang Li et al.

Oncology letters, 23(4), 129-129 (2022-03-08)

Recent studies have shown that the Eph receptor A2 (EphA2) and its inhibitor ALW-II-41-27 could regulate various cellular processes in several types of cancer. However, the manner in which ALW-II-41-27 affects the development of cervical cancer (CC) remains unknown. The

Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.

Michael S Samuel et al.

Genesis (New York, N.Y. : 2000), 54(12), 636-646 (2016-10-25)

The serine/threonine kinases ROCK1 and ROCK2 are central mediators of actomyosin contractile force generation that act downstream of the RhoA small GTP-binding protein. As a result, they have key roles in regulating cell morphology and proliferation, and have been implicated

A Ser75-to-Asp phospho-mimicking mutation in Src accelerates ageing-related loss of retinal ganglion cells in mice.

Kenji Kashiwagi et al.

Scientific reports, 7(1), 16779-16779 (2017-12-03)

Src knockout mice show no detectable abnormalities in central nervous system (CNS) post-mitotic neurons, likely reflecting functional compensation by other Src family kinases. Cdk1- or Cdk5-dependent Ser75 phosphorylation in the amino-terminal Unique domain of Src, which shares no homology with

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