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Documentos Principais

05-1100-M

Sigma-Aldrich

Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2

clone Sulfo-1C-A2, Upstate®, from mouse

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About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

100

forma do anticorpo

culture supernatant

tipo de produto de anticorpo

primary antibodies

clone

Sulfo-1C-A2, monoclonal

reatividade de espécies

human, mouse, bovine, porcine

reatividade da espécie (prevista por homologia)

all

fabricante/nome comercial

Upstate®

técnica(s)

ELISA: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Isotipo

IgG2aκ

Descrição geral

Sulfotyrosine is a common post-translational modification of secretory, plasma membrane, and lysosomal proteins. The sulfation reaction is catalyzed by specific sulfotransferase enzymes in the trans-Golgi-network. Tyrosine sulfation occurs in all multicellular organisms and up to 1% of the tyrosines in the total protein content of a cell can be sulfated. Sulfotyrosines mediates many receptor-ligand binding interactions, including the interaction of P-selectin glycoprotein ligand-1 with P-selectin, factor VIII binding to von Willebrand factor, and interactions between thrombin and hirudin. Sulfotyrosine is also involved in the entry of several parasites and viruses; for example, tyrosine sulfation of the HIV-1 co-receptor CCR5 is required for viral entry into host cells, and tyrosine sulfation of the Duffy antigen/receptor for chemokines is crucial for erythrocyte invasion by the malaria parasite Plasmodium vivax.

This clone was derived from the antibody described in Kehoe et al., 2006.

Especificidade

The antibody is predicted to recognize any sulfotyrosine, regardless of surrounding amino acid sequence.

Aplicação

Detect Sulfotyrosine with Anti-Sulfotyrosine Antibody, Clone Sulfo-1C-A2 (Mouse Monoclonal Antibody), that has been shown to work in WB, IP, ELISA.

Qualidade

Assayed using sulfatase treated bovine fibrinogen vs. untreated fibrinogen.

Descrição-alvo

n/a

forma física

Format: Purified

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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