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T-049

Supelco

Tacrolimus solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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1 ML
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About This Item

Fórmula empírica (Notação de Hill):
C44H69NO12
Número CAS:
104987-11-3
Peso molecular:
804.02
Número MDL:
MFCD00869853
Código UNSPSC:
41116107
ID de substância PubChem:
329826607
NACRES:
NA.24

R$ 1.639,00

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grau

certified reference material

Nível de qualidade

300

Formulário

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

embalagem

ampule of 1 mL

fabricante/nome comercial

Cerilliant®

concentração

1.0 mg/mL in acetonitrile

técnica(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicação(ões)

clinical testing

Formato

single component solution

temperatura de armazenamento

−70°C

cadeia de caracteres SMILES

CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC

InChI

1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

chave InChI

QJJXYPPXXYFBGM-LFZNUXCKSA-N

Informações sobre genes

human ... FKBP1A(2280)

Categorias relacionadas

Descrição geral

Tacrolimus, also known as fujimycin, is an immunosuppressant used to prevent rejection of organ transplants. This Certified Spiking Solution® is suitable for use as starting material in the preparation of calibrators and controls for tacrolimus testing methods by LC-MS/MS. Tacrolimus is sold under trade names Progaf, Advagraf®, and Protopic®.

Informações legais

Advagraf is a registered trademark of Astellas Pharma Inc.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Protopic is a registered trademark of Astellas Pharma Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

FlameExclamation mark
GHS02,GHS07

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Código de classe de armazenamento

3 - Flammable liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

35.6 °F - closed cup

Ponto de fulgor (°C)

2 °C - closed cup

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Certificados de análise (COA)

Lot/Batch Number

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Sigma-Aldrich

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Tomohiro Tsuchiya et al.
Transplantation, 96(2), 198-204 (2013-06-25)
A prolonged-release formulation of tacrolimus (Tacrolimus QD) was developed to allow once-daily dosing and to have similar safety and efficacy profiles to twice-daily tacrolimus (Tacrolimus BID). This study compared the pharmacokinetics (PK) and renal pathology by protocol biopsy in de
[Successful effect of tacrolimus in a 5-year-old boy presenting with repeated episodes of non-herpetic acute limbic encephalitis].
K Kishi et al.
No to hattatsu = Brain and development, 45(2), 152-154 (2013-05-09)
Markus Riegersperger et al.
Transplantation, 95(11), 1338-1345 (2013-04-19)
Endothelial progenitor cell (EPC) counts are proposed surrogate markers for vascular function and cardiovascular risk. The effect of tacrolimus (TAC) on EPC is unknown. In this randomized controlled trial, we assigned 148 stable long-term kidney transplant recipients (KTR) to maintaining
Darla R Lower et al.
American journal of clinical pathology, 139(6), 788-792 (2013-05-22)
FK506 (tacrolimus), a macrolide immunosuppressant, is widely used in pediatric transplant patients, but a relatively narrow therapeutic window in children vs adults requires close and accurate monitoring of whole blood FK506 levels. High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS/MS)-based assays have
Kensuke Kosugi et al.
Cranio : the journal of craniomandibular practice, 31(2), 140-150 (2013-06-26)
The authors performed a longitudinal study of the microstructural changes occurring in the mandibular condyle during osteoporosis using the findings obtained from micro-CT. The subjects used in this study were eight Sprague-Dawley rats. Among them, five were administered the immunosuppressant
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