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890704C

Avanti

18:1 EPC (Cl Salt)

Avanti Research™ - A Croda Brand 890704C

Sinônimo(s):

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)

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About This Item

Fórmula empírica (Notação de Hill):
C46H89NO8PCl
Número CAS:
474945-24-9
Peso molecular:
850.63
Código UNSPSC:
12352211
NACRES:
NA.25

forma

liquid

embalagem

pkg of 1 × 2.5 mL (890704C-25mg)
pkg of 1 × 4 mL (890704C-100mg)
pkg of 2 × 4 mL (890704C-200mg)

fabricante/nome comercial

Avanti Research™ - A Croda Brand 890704C

concentração

10 mg/mL (890704C-25mg)
25 mg/mL (890704C-100mg)
25 mg/mL (890704C-200mg)

tipo de lipídio

transfection
cationic lipids

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)OCC.[Cl-]

Descrição geral

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) is a cationic alkylated phospholipid.

Aplicação

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (18:1 EPC (Cl Salt)) is suitable:
  • for composing lipid shell to prepare lipopolyplex/mRNA vaccine
  • in solvent-assisted preparation of supported lipid bilayers
  • along with 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) in mixed liposomes as colloidal vectors for physicochemical study of the DNA compaction
  • to formulate the lipid nanoparticle (LNP1) to enhance intracellular delivery mediated by shock waves

Ações bioquímicas/fisiológicas

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) serves as a transfection reagent. 18:1 EPC is applicable in liposomes and lipoplexes. It is a potential vector in gene therapy.

Embalagem

5 mL Clear Glass Sealed Ampule (890704C-100mg)
5 mL Clear Glass Sealed Ampule (890704C-200mg)
5 mL Clear Glass Sealed Ampule (890704C-25mg)

Informações legais

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

Órgãos-alvo

Liver,Kidney, Respiratory system

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Gene vectors based on DOEPC/DOPE mixed cationic liposomes: a physicochemical study
Munoz U, et al.
Soft Matter, 7(13), 5991-6004 (2011)
Abdul Rahim Ferhan et al.
Nature protocols, 14(7), 2091-2118 (2019-06-09)
The supported lipid bilayer (SLB) platform is a popular cell membrane mimic that is utilized in the chemical, biological, materials science, and medical fields. To date, SLB preparation has proven challenging because of the need for specialized fabrication equipment, domain-specific
Stefano Persano et al.
Biomaterials, 125, 81-89 (2017-02-24)
mRNA-based vaccines have the benefit of triggering robust anti-cancer immunity without the potential danger of genome integration from DNA vaccines or the limitation of antigen selection from peptide vaccines. Yet, a conventional mRNA vaccine comprising of condensed mRNA molecules in
Jing Zhang et al.
ACS applied materials & interfaces, 11(11), 10481-10491 (2019-02-23)
Cellular membranes are, in general, impermeable to macromolecules (herein referred to as macrodrugs, e.g., recombinant protein, expression plasmids, or mRNA), which is a major barrier for clinical translation of macrodrug-based therapies. Encapsulation of macromolecules in lipid nanoparticles (LNPs) can protect
Kabir H Biswas et al.
Langmuir : the ACS journal of surfaces and colloids, 34(4), 1775-1782 (2017-12-28)
The pathway of vesicle adsorption onto a solid support depends on the material composition of the underlying support, and there is significant interest in developing material-independent strategies to modulate the spectrum of vesicle-substrate interactions on a particular surface. Herein, using
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